Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial Fibrillation
Lessard, Darleen M.
Saczynski, Jane S.
McManus, David D.
Silverman-Lloyd, Luke G.
Benson, Christopher M.
Blaha, Michael J.
Waring, Molly E.
UMass Chan AffiliationsDepartment of Population and Quantitative Health Sciences
Division of Cardiovascular Medicine, Department of Medicine
quality of life
Musculoskeletal, Neural, and Ocular Physiology
Psychiatry and Psychology
Psychological Phenomena and Processes
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AbstractBackground: Low gait speed has been linked with impaired mood, cognition, and quality of life (QOL) in older adults. We examined whether low gait speed was associated with impaired mood, cognition, and QOL among older adults with atrial fibrillation (AF). Methods and Results: Participants (n=1185) had a diagnosis of AF, aged > /=65 years, CHA2DS2VASc > /=2 and had no contraindications to anticoagulation. Participants completed a 15-foot walk test, and low gait speed was categorized using cutoffs from the Fried Frailty Index. Participants self-reported measures of depressive symptoms (Patient Health Questionnaire 9 > /=10), anxiety symptoms (Generalized Anxiety Disorder 7 > /=10), cognitive impairment (Montreal Cognitive Assessment < /=23), and potentially impaired Atrial Fibrillation Effect Quality-of-Life Questionnaire < 80. Participants were on average aged 75.3 (SD: 7.0) years, 48.0% were women, and 85.5% were non-Hispanic white; 85.6% were taking an oral anticoagulant, 26.1% had low gait speed, 8.4% had elevated depressive symptoms, 5.7% had elevated anxiety symptoms, 41.1% were cognitively impaired, and 41.6% had potentially impaired AF-related QOL. Participants with low gait speed were significantly more likely to have elevated depressive symptoms (adjusted odds ratio: 2.1, 95% CI: 1.3-3.4), elevated anxiety symptoms (adjusted odds ratio: 2.2, 95% CI: 1.2-3.9), and cognitive impairment (adjusted odds ratio: 1.5, 95% CI: 1.1-2.1). Impaired AF-related QOL did not differ by gait speed after adjustment for clinical characteristics (adjusted odds ratio: 1.1, 95% CI: 0.8-1.5). Conclusions: Twenty-six percent of older adults with AF had low gait speed, and low gait speed was associated with impaired mood and cognition. Further research is needed to determine whether declines in gait speed lead to impaired mood and cognition or whether these conditions develop concurrently.
J Am Heart Assoc. 2019 Nov 19;8(22):e013212. doi: 10.1161/JAHA.119.013212. Epub 2019 Nov 16. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/41259
RightsCopyright 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modiﬁcations or adaptations are made.
Except where otherwise noted, this item's license is described as Copyright 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modiﬁcations or adaptations are made.