Show simple item record

dc.contributor.authorSava, Vasyl
dc.contributor.authorFihurka, Oksana
dc.contributor.authorKhvorova, Anastasia
dc.contributor.authorSanchez-Ramos, Juan
dc.date2022-08-11T08:09:55.000
dc.date.accessioned2022-08-23T16:48:45Z
dc.date.available2022-08-23T16:48:45Z
dc.date.issued2020-02-01
dc.date.submitted2020-02-18
dc.identifier.citation<p>Sava V, Fihurka O, Khvorova A, Sanchez-Ramos J. Data on enrichment of chitosan nanoparticles for intranasal delivery of oligonucleotides to the brain. Data Brief. 2020 Jan 3;28:105093. doi: 10.1016/j.dib.2019.105093. PMID: 31970274; PMCID: PMC6965707. <a href="https://doi.org/10.1016/j.dib.2019.105093">Link to article on publisher's site</a></p>
dc.identifier.issn2352-3409 (Linking)
dc.identifier.doi10.1016/j.dib.2019.105093
dc.identifier.pmid31970274
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41328
dc.description.abstractData on preparation and characterization of chitosan-based nanoparticles (NP) carrying small interfering RNA (siRNA) for non-invasive gene therapy is presented. Polyelectrolyte complexation method was carried out in diluted concentrations to obtain relatively small (less than 200 nm) NP. To provide substantial dose of siRNA within tolerable volume of intranasal administration the NP were subjected to enrichment process. Offered here NP fabrication does two steps process comprise provisional and enriched preparations? The differences between these preparations were analyzed with hydrodynamic size distribution and zeta potential measurements. The effect of siRNA lipophilicity on NP physical instability was also tested. Biological evaluation of nanoparticles is described in our published article [1].
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=31970274&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights© 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectChitosan
dc.subjectEnrichment
dc.subjectNanocarriers
dc.subjectPolyelectrolyte complexation
dc.subjectsiRNA
dc.subjectAnalytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subjectGenetics and Genomics
dc.subjectLaboratory and Basic Science Research
dc.subjectNanomedicine
dc.subjectNervous System
dc.subjectNucleic Acids, Nucleotides, and Nucleosides
dc.titleData on enrichment of chitosan nanoparticles for intranasal delivery of oligonucleotides to the brain
dc.typeJournal Article
dc.source.journaltitleData in brief
dc.source.volume28
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5131&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4112
dc.identifier.contextkey16574424
refterms.dateFOA2022-08-23T16:48:45Z
html.description.abstract<p>Data on preparation and characterization of chitosan-based nanoparticles (NP) carrying small interfering RNA (siRNA) for non-invasive gene therapy is presented. Polyelectrolyte complexation method was carried out in diluted concentrations to obtain relatively small (less than 200 nm) NP. To provide substantial dose of siRNA within tolerable volume of intranasal administration the NP were subjected to enrichment process. Offered here NP fabrication does two steps process comprise provisional and enriched preparations? The differences between these preparations were analyzed with hydrodynamic size distribution and zeta potential measurements. The effect of siRNA lipophilicity on NP physical instability was also tested. Biological evaluation of nanoparticles is described in our published article [1].</p>
dc.identifier.submissionpathoapubs/4112
dc.contributor.departmentRNA Therapeutics Institute
dc.source.pages105093


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
1_s2.0_S2352340919314490_main.pdf
Size:
413.2Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

© 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).