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dc.contributor.authorFischer, Kathrin I.
dc.contributor.authorFischer, Felix H.
dc.contributor.authorBarthel, Dana
dc.contributor.authorOtto, Christiane
dc.contributor.authorThyen, Ute
dc.contributor.authorKlein, Marcus
dc.contributor.authorWalter, Otto
dc.contributor.authorRavens-Sieberer, Ulrike
dc.contributor.authorRose, Matthias S. F.
dc.contributor.authorNolte, Sandra
dc.date2022-08-11T08:09:55.000
dc.date.accessioned2022-08-23T16:48:46Z
dc.date.available2022-08-23T16:48:46Z
dc.date.issued2020-01-21
dc.date.submitted2020-02-18
dc.identifier.citation<p>Fischer KI, Fischer FH, Barthel D, Otto C, Thyen U, Klein M, Walter O, Ravens-Sieberer U, Rose M, Nolte S. Trajectories of Health-Related Quality of Life and HbA1c Values of Children and Adolescents With Diabetes Mellitus Type 1 Over 6 Months: A Longitudinal Observational Study. Front Pediatr. 2020 Jan 21;7:566. doi: 10.3389/fped.2019.00566. PMID: 32039122; PMCID: PMC6986264. <a href="https://doi.org/10.3389/fped.2019.00566">Link to article on publisher's site</a></p>
dc.identifier.issn2296-2360 (Linking)
dc.identifier.doi10.3389/fped.2019.00566
dc.identifier.pmid32039122
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41332
dc.description.abstractIntroduction: To achieve optimized blood glucose concentrations (assessed by HbA1c) and high health-related quality of life (HRQL), children and adolescents with diabetes mellitus type 1 (T1DM) must follow strict disease management strategies. This study aims to investigate HRQL of children and adolescents with T1DM and its association with HbA1c values over the course of 6 months. Methods: Patients aged 7-17 years (n = 203) with T1DM provided HRQL data on a monthly basis. HRQL was measured using the Kids-CAT, a computer-adaptive test (CAT) comprising five generic HRQL domains. HbA1c concentrations were assessed at baseline, at 3 and 6 months. We explored the trajectory of HRQL at the domain level using linear mixed effects models. Further, we investigated the association between HRQL and HbA1c concentrations over time using path analysis models. Results: Children and adolescents with T1DM reported high scores across all HRQL domains over time. However, those with an HbA1c concentrations of > 9.0% reported significantly lower scores in physical well-being and parent relations compared with those with an HbA1c concentration of < 7.5%. Path analysis models revealed a minimal temporal relationship between HbA1c and HRQL, with a small negative impact of HbA1c on physical well-being, psychological well-being and parent relations. Conclusion: Although observed HRQL of young patients with T1DM was comparable to age-related German-speaking reference population over the course of 6 months, those with an HbA1c concentration > 9.0% reported lower scores in selected HRQL domains. Thus, special attention should be drawn to HRQL of children and adolescents with higher HbA1c concentrations. The minimal relationship between HbA1c and HRQL indicates that the two therapy goals, i.e., achievement and maintenance of glycemic targets and high HRQL, should be considered and evaluated independently in clinical routine. Trial Registration: DRKS00006326 (German Clinical Trial Register), date of registration: August 1st, 2014.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32039122&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2020 Fischer, Fischer, Barthel, Otto, Thyen, Klein, Walter, Ravens-Sieberer, Rose and Nolte. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectcomputer-adaptive testing
dc.subjectdiabetes mellitus type 1
dc.subjecthealth-related quality of life
dc.subjectpatient outcome assessments
dc.subjectpediatrics
dc.subjectself-report
dc.subjectClinical Epidemiology
dc.subjectEndocrine System Diseases
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.subjectEpidemiology
dc.subjectHealth Services Administration
dc.subjectImmune System Diseases
dc.subjectNutritional and Metabolic Diseases
dc.subjectPediatrics
dc.titleTrajectories of Health-Related Quality of Life and HbA1c Values of Children and Adolescents With Diabetes Mellitus Type 1 Over 6 Months: A Longitudinal Observational Study
dc.typeJournal Article
dc.source.journaltitleFrontiers in pediatrics
dc.source.volume7
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5136&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4117
dc.identifier.contextkey16574429
refterms.dateFOA2022-08-23T16:48:47Z
html.description.abstract<p>Introduction: To achieve optimized blood glucose concentrations (assessed by HbA1c) and high health-related quality of life (HRQL), children and adolescents with diabetes mellitus type 1 (T1DM) must follow strict disease management strategies. This study aims to investigate HRQL of children and adolescents with T1DM and its association with HbA1c values over the course of 6 months.</p> <p>Methods: Patients aged 7-17 years (n = 203) with T1DM provided HRQL data on a monthly basis. HRQL was measured using the Kids-CAT, a computer-adaptive test (CAT) comprising five generic HRQL domains. HbA1c concentrations were assessed at baseline, at 3 and 6 months. We explored the trajectory of HRQL at the domain level using linear mixed effects models. Further, we investigated the association between HRQL and HbA1c concentrations over time using path analysis models.</p> <p>Results: Children and adolescents with T1DM reported high scores across all HRQL domains over time. However, those with an HbA1c concentrations of > 9.0% reported significantly lower scores in physical well-being and parent relations compared with those with an HbA1c concentration of < 7.5%. Path analysis models revealed a minimal temporal relationship between HbA1c and HRQL, with a small negative impact of HbA1c on physical well-being, psychological well-being and parent relations.</p> <p>Conclusion: Although observed HRQL of young patients with T1DM was comparable to age-related German-speaking reference population over the course of 6 months, those with an HbA1c concentration > 9.0% reported lower scores in selected HRQL domains. Thus, special attention should be drawn to HRQL of children and adolescents with higher HbA1c concentrations. The minimal relationship between HbA1c and HRQL indicates that the two therapy goals, i.e., achievement and maintenance of glycemic targets and high HRQL, should be considered and evaluated independently in clinical routine.</p> <p>Trial Registration: DRKS00006326 (German Clinical Trial Register), date of registration: August 1st, 2014.</p>
dc.identifier.submissionpathoapubs/4117
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pages566


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Copyright © 2020 Fischer, Fischer, Barthel, Otto, Thyen, Klein, Walter, Ravens-Sieberer, Rose and Nolte. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as Copyright © 2020 Fischer, Fischer, Barthel, Otto, Thyen, Klein, Walter, Ravens-Sieberer, Rose and Nolte. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.