Authors
Han, Myoung SoukWhite, Alexis
Perry, Rachel J.
Camporez, Joao-Paulo
Hidalgo, Juan
Shulman, Gerald I.
Davis, Roger J.
Document Type
Journal ArticlePublication Date
2020-02-11Keywords
adipose tissueinflammation
insulin resistance
interleukin 6
Amino Acids, Peptides, and Proteins
Biochemical Phenomena, Metabolism, and Nutrition
Cell Biology
Cellular and Molecular Physiology
Endocrinology, Diabetes, and Metabolism
Hemic and Immune Systems
Nutritional and Metabolic Diseases
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Show full item recordAbstract
Obesity is associated with a chronic state of low-grade inflammation and progressive tissue infiltration by immune cells and increased expression of inflammatory cytokines. It is established that interleukin 6 (IL6) regulates multiple aspects of metabolism, including glucose disposal, lipolysis, oxidative metabolism, and energy expenditure. IL6 is secreted by many tissues, but the role of individual cell types is unclear. We tested the role of specific cells using a mouse model with conditional expression of the Il6 gene. We found that IL6 derived from adipocytes increased, while IL6 derived from myeloid cells and muscle suppressed, macrophage infiltration of adipose tissue. These opposite actions were associated with a switch of IL6 signaling from a canonical mode (myeloid cells) to a noncanonical trans-signaling mode (adipocytes and muscle) with increased expression of the ADAM10/17 metalloprotease that promotes trans-signaling by the soluble IL6 receptor alpha. Collectively, these data demonstrate that the source of IL6 production plays a major role in the physiological regulation of metabolism.Source
Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2751-2760. doi: 10.1073/pnas.1920004117. Epub 2020 Jan 24. PMID: 31980524; PMCID: PMC7022151. Link to article on publisher's site
DOI
10.1073/pnas.1920004117Permanent Link to this Item
http://hdl.handle.net/20.500.14038/41361PubMed ID
31980524Related Resources
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Copyright © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1073/pnas.1920004117
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Except where otherwise noted, this item's license is described as Copyright © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).