Show simple item record

dc.contributor.authorHan, Myoung Souk
dc.contributor.authorWhite, Alexis
dc.contributor.authorPerry, Rachel J.
dc.contributor.authorCamporez, Joao-Paulo
dc.contributor.authorHidalgo, Juan
dc.contributor.authorShulman, Gerald I.
dc.contributor.authorDavis, Roger J.
dc.date2022-08-11T08:09:55.000
dc.date.accessioned2022-08-23T16:48:55Z
dc.date.available2022-08-23T16:48:55Z
dc.date.issued2020-02-11
dc.date.submitted2020-02-25
dc.identifier.citation<p>Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2751-2760. doi: 10.1073/pnas.1920004117. Epub 2020 Jan 24. PMID: 31980524; PMCID: PMC7022151. <a href="https://doi.org/10.1073/pnas.1920004117">Link to article on publisher's site</a></p>
dc.identifier.issn0027-8424 (Linking)
dc.identifier.doi10.1073/pnas.1920004117
dc.identifier.pmid31980524
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41361
dc.description.abstractObesity is associated with a chronic state of low-grade inflammation and progressive tissue infiltration by immune cells and increased expression of inflammatory cytokines. It is established that interleukin 6 (IL6) regulates multiple aspects of metabolism, including glucose disposal, lipolysis, oxidative metabolism, and energy expenditure. IL6 is secreted by many tissues, but the role of individual cell types is unclear. We tested the role of specific cells using a mouse model with conditional expression of the Il6 gene. We found that IL6 derived from adipocytes increased, while IL6 derived from myeloid cells and muscle suppressed, macrophage infiltration of adipose tissue. These opposite actions were associated with a switch of IL6 signaling from a canonical mode (myeloid cells) to a noncanonical trans-signaling mode (adipocytes and muscle) with increased expression of the ADAM10/17 metalloprotease that promotes trans-signaling by the soluble IL6 receptor alpha. Collectively, these data demonstrate that the source of IL6 production plays a major role in the physiological regulation of metabolism.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=31980524&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996105/
dc.rightsCopyright © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectadipose tissue
dc.subjectinflammation
dc.subjectinsulin resistance
dc.subjectinterleukin 6
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectBiochemical Phenomena, Metabolism, and Nutrition
dc.subjectCell Biology
dc.subjectCellular and Molecular Physiology
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.subjectHemic and Immune Systems
dc.subjectNutritional and Metabolic Diseases
dc.titleRegulation of adipose tissue inflammation by interleukin 6
dc.typeJournal Article
dc.source.journaltitleProceedings of the National Academy of Sciences of the United States of America
dc.source.volume117
dc.source.issue6
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5163&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4144
dc.identifier.contextkey16652284
refterms.dateFOA2022-08-23T16:48:55Z
html.description.abstract<p>Obesity is associated with a chronic state of low-grade inflammation and progressive tissue infiltration by immune cells and increased expression of inflammatory cytokines. It is established that interleukin 6 (IL6) regulates multiple aspects of metabolism, including glucose disposal, lipolysis, oxidative metabolism, and energy expenditure. IL6 is secreted by many tissues, but the role of individual cell types is unclear. We tested the role of specific cells using a mouse model with conditional expression of the Il6 gene. We found that IL6 derived from adipocytes increased, while IL6 derived from myeloid cells and muscle suppressed, macrophage infiltration of adipose tissue. These opposite actions were associated with a switch of IL6 signaling from a canonical mode (myeloid cells) to a noncanonical trans-signaling mode (adipocytes and muscle) with increased expression of the ADAM10/17 metalloprotease that promotes trans-signaling by the soluble IL6 receptor alpha. Collectively, these data demonstrate that the source of IL6 production plays a major role in the physiological regulation of metabolism.</p>
dc.identifier.submissionpathoapubs/4144
dc.contributor.departmentDavis Lab
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages2751-2760


Files in this item

Thumbnail
Name:
2751.full.pdf
Size:
2.149Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Copyright © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
Except where otherwise noted, this item's license is described as Copyright © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).