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dc.contributor.authorThulin, Natalie K.
dc.contributor.authorBrewer, R. Camille
dc.contributor.authorSherwood, Robert
dc.contributor.authorBournazos, Stylianos
dc.contributor.authorEdwards, Karlie G.
dc.contributor.authorRamadoss, Nitya S.
dc.contributor.authorTaubenberger, Jeffery K.
dc.contributor.authorMemoli, Matthew
dc.contributor.authorGentles, Andrew J.
dc.contributor.authorJagannathan, Prasanna
dc.contributor.authorZhang, Sheng
dc.contributor.authorLibraty, Daniel H.
dc.contributor.authorWang, Taia T.
dc.date2022-08-11T08:09:56.000
dc.date.accessioned2022-08-23T16:49:25Z
dc.date.available2022-08-23T16:49:25Z
dc.date.issued2020-05-12
dc.date.submitted2020-06-05
dc.identifier.citation<p>Thulin NK, Brewer RC, Sherwood R, Bournazos S, Edwards KG, Ramadoss NS, Taubenberger JK, Memoli M, Gentles AJ, Jagannathan P, Zhang S, Libraty DH, Wang TT. Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants. Cell Rep. 2020 May 12;31(6):107642. doi: 10.1016/j.celrep.2020.107642. PMID: 32402275. <a href="https://doi.org/10.1016/j.celrep.2020.107642">Link to article on publisher's site</a></p>
dc.identifier.issn2211-1247 (Electronic)
dc.identifier.doi10.1016/j.celrep.2020.107642
dc.identifier.pmid32402275
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41458
dc.description.abstractInfant mortality from dengue disease is a devastating global health burden that could be minimized with the ability to identify susceptibility for severe disease prior to infection. Although most primary infant dengue infections are asymptomatic, maternally derived anti-dengue immunoglobulin G (IgGs) present during infection can trigger progression to severe disease through antibody-dependent enhancement mechanisms. Importantly, specific characteristics of maternal IgGs that herald progression to severe infant dengue are unknown. Here, we define > /=10% afucosylation of maternal anti-dengue IgGs as a risk factor for susceptibility of infants to symptomatic dengue infections. Mechanistic experiments show that afucosylation of anti-dengue IgGs promotes FcgammaRIIIa signaling during infection, in turn enhancing dengue virus replication in FcgammaRIIIa(+) monocytes. These studies identify a post-translational modification of anti-dengue IgGs that correlates with risk for symptomatic infant dengue infections and define a mechanism by which afucosylated antibodies and FcgammaRIIIa enhance dengue infections.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32402275&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCD16
dc.subjectFcγRIIIa
dc.subjectIgG fucosylation
dc.subjectantibody glycosylation
dc.subjectinfant dengue
dc.subjectsevere dengue
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectImmunology of Infectious Disease
dc.subjectImmunopathology
dc.subjectInfectious Disease
dc.subjectMaternal and Child Health
dc.subjectVirus Diseases
dc.titleMaternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants
dc.typeJournal Article
dc.source.journaltitleCell reports
dc.source.volume31
dc.source.issue6
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5256&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4237
dc.identifier.contextkey17992627
refterms.dateFOA2022-08-23T16:49:25Z
html.description.abstract<p>Infant mortality from dengue disease is a devastating global health burden that could be minimized with the ability to identify susceptibility for severe disease prior to infection. Although most primary infant dengue infections are asymptomatic, maternally derived anti-dengue immunoglobulin G (IgGs) present during infection can trigger progression to severe disease through antibody-dependent enhancement mechanisms. Importantly, specific characteristics of maternal IgGs that herald progression to severe infant dengue are unknown. Here, we define > /=10% afucosylation of maternal anti-dengue IgGs as a risk factor for susceptibility of infants to symptomatic dengue infections. Mechanistic experiments show that afucosylation of anti-dengue IgGs promotes FcgammaRIIIa signaling during infection, in turn enhancing dengue virus replication in FcgammaRIIIa(+) monocytes. These studies identify a post-translational modification of anti-dengue IgGs that correlates with risk for symptomatic infant dengue infections and define a mechanism by which afucosylated antibodies and FcgammaRIIIa enhance dengue infections.</p>
dc.identifier.submissionpathoapubs/4237
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages107642


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Copyright 2020 The Author(s).  This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as Copyright 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/