UMass Chan Affiliations
Graduate School of Biomedical SciencesDepartment of Molecular, Cell, and Cancer Biology
Program in Molecular Medicine
Document Type
Journal ArticlePublication Date
2020-05-22Keywords
Melanomagenetics
melanocytes
microenvironment
modeling
xenografts
zebrafish
Animal Experimentation and Research
Cancer Biology
Disease Modeling
Genetics and Genomics
Molecular Biology
Neoplasms
Metadata
Show full item recordAbstract
Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity. Zebrafish-due in large part to their tractable genetics, conserved pathways, and optical properties-have emerged as an excellent system to model melanoma. Zebrafish have been used to study melanoma from a single tumor initiating cell, through metastasis, remission, and finally into relapse. In this review, we examine seminal zebrafish studies that have advanced our understanding of melanoma.Source
Frantz WT, Ceol CJ. From Tank to Treatment: Modeling Melanoma in Zebrafish. Cells. 2020 May 22;9(5):E1289. doi: 10.3390/cells9051289. PMID: 32455885. Link to article on publisher's site
DOI
10.3390/cells9051289Permanent Link to this Item
http://hdl.handle.net/20.500.14038/41460PubMed ID
32455885Related Resources
Rights
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.3390/cells9051289
Scopus Count
Except where otherwise noted, this item's license is described as © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).