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dc.contributor.authorCorrigan, June K.
dc.contributor.authorRamachandran, Deepti
dc.contributor.authorHe, Yuchen
dc.contributor.authorPalmer, Colin J.
dc.contributor.authorJurczak, Michael J.
dc.contributor.authorChen, Rui
dc.contributor.authorLi, Bingshan
dc.contributor.authorFriedline, Randall H.
dc.contributor.authorKim, Jason K.
dc.contributor.authorRamsey, Jon J.
dc.contributor.authorLantier, Louise
dc.contributor.authorMcGuinness, Owen P.
dc.contributor.authorBanks, Alexander S.
dc.date2022-08-11T08:09:56.000
dc.date.accessioned2022-08-23T16:49:26Z
dc.date.available2022-08-23T16:49:26Z
dc.date.issued2020-05-01
dc.date.submitted2020-06-09
dc.identifier.citation<p>Corrigan JK, Ramachandran D, He Y, Palmer CJ, Jurczak MJ, Chen R, Li B, Friedline RH, Kim JK, Ramsey JJ, Lantier L, McGuinness OP; Mouse Metabolic Phenotyping Center Energy Balance Working Group, Banks AS. A big-data approach to understanding metabolic rate and response to obesity in laboratory mice. Elife. 2020 May 1;9:e53560. doi: 10.7554/eLife.53560. PMID: 32356724; PMCID: PMC7274785. <a href="https://doi.org/10.7554/eLife.53560">Link to article on publisher's site</a></p>
dc.identifier.issn2050-084X (Linking)
dc.identifier.doi10.7554/eLife.53560
dc.identifier.pmid32356724
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41463
dc.description.abstractMaintaining a healthy body weight requires an exquisite balance between energy intake and energy expenditure. To understand the genetic and environmental factors that contribute to the regulation of body weight, an important first step is to establish the normal range of metabolic values and primary sources contributing to variability. Energy metabolism is measured by powerful and sensitive indirect calorimetry devices. Analysis of nearly 10,000 wild-type mice from two large-scale experiments revealed that the largest variation in energy expenditure is due to body composition, ambient temperature, and institutional site of experimentation. We also analyze variation in 2329 knockout strains and establish a reference for the magnitude of metabolic changes. Based on these findings, we provide suggestions for how best to design and conduct energy balance experiments in rodents. These recommendations will move us closer to the goal of a centralized physiological repository to foster transparency, rigor and reproducibility in metabolic physiology experimentation.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32356724&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2020, Corrigan et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectenergy expenditure
dc.subjectfood intake
dc.subjectgenetics
dc.subjecthuman biology
dc.subjectmedicine
dc.subjectmetabolic rate
dc.subjectmouse
dc.subjectneuroscience
dc.subjectobesity
dc.subjectthermogenesis
dc.subjectBiochemical Phenomena, Metabolism, and Nutrition
dc.subjectBioinformatics
dc.subjectCellular and Molecular Physiology
dc.subjectNutritional and Metabolic Diseases
dc.subjectPhysiological Processes
dc.subjectResearch Methods in Life Sciences
dc.titleA big-data approach to understanding metabolic rate and response to obesity in laboratory mice
dc.typeJournal Article
dc.source.journaltitleeLife
dc.source.volume9
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5260&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4241
dc.identifier.contextkey18035202
refterms.dateFOA2022-08-23T16:49:27Z
html.description.abstract<p>Maintaining a healthy body weight requires an exquisite balance between energy intake and energy expenditure. To understand the genetic and environmental factors that contribute to the regulation of body weight, an important first step is to establish the normal range of metabolic values and primary sources contributing to variability. Energy metabolism is measured by powerful and sensitive indirect calorimetry devices. Analysis of nearly 10,000 wild-type mice from two large-scale experiments revealed that the largest variation in energy expenditure is due to body composition, ambient temperature, and institutional site of experimentation. We also analyze variation in 2329 knockout strains and establish a reference for the magnitude of metabolic changes. Based on these findings, we provide suggestions for how best to design and conduct energy balance experiments in rodents. These recommendations will move us closer to the goal of a centralized physiological repository to foster transparency, rigor and reproducibility in metabolic physiology experimentation.</p>
dc.identifier.submissionpathoapubs/4241
dc.contributor.departmentDivision of Endocrinology, Metabolism, and Diabetes, Department of Medicine
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pagese53560


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Copyright © 2020, Corrigan et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright © 2020, Corrigan et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.