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dc.contributor.authorCastro-Diehl, Cecilia
dc.contributor.authorSong, Rebecca J.
dc.contributor.authorMitchell, Gary F.
dc.contributor.authorMcManus, David D.
dc.contributor.authorCheng, Susan
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorXanthakis, Vanessa
dc.date2022-08-11T08:09:56.000
dc.date.accessioned2022-08-23T16:49:32Z
dc.date.available2022-08-23T16:49:32Z
dc.date.issued2020-05-15
dc.date.submitted2020-06-23
dc.identifier.citation<p>Castro-Diehl C, Song RJ, Mitchell GF, McManus D, Cheng S, Vasan RS, Xanthakis V. Association of subclinical atherosclerosis with echocardiographic indices of cardiac remodeling: The Framingham Study. PLoS One. 2020 May 15;15(5):e0233321. doi: 10.1371/journal.pone.0233321. PMID: 32413074; PMCID: PMC7228064. <a href="https://doi.org/10.1371/journal.pone.0233321">Link to article on publisher's site</a></p>
dc.identifier.issn1932-6203 (Linking)
dc.identifier.doi10.1371/journal.pone.0233321
dc.identifier.pmid32413074
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41482
dc.description.abstractBACKGROUND: It is well established that coronary artery disease progresses along with myocardial disease. However, data on the association between coronary artery calcium (CAC) and echocardiographic variables are lacking. METHODS AND RESULTS: Among 2,650 Framingham Study participants (mean age 51 yrs, 48% women; 40% with CAC > 0), we related CT-based CAC score to left ventricular (LV) mass index (LVMi), LV ejection fraction (LVEF), E/e', global longitudinal strain (GLS), left atrial emptying fraction (LAEF), and aortic root diameter (AoR), using multivariable-adjusted generalized linear models. CAC score (independent variable) was used as log-transformed continuous [ln(CAC+1)] and as a categorical (0, 1-100, and > /=101) variable. Adjusting for standard risk factors, higher CAC score was associated with higher LVMi and AoR (betaLVMI per 1-SD increase 0.012, betaAoR 0.008; P < 0.05, for both). Participants with 1 < /=CAC < /=100 and those with CAC > /=101 had higher AoR (betaAoR 0.013 and 0.020, respectively, P = 0.01) than those with CAC = 0. CAC score was not significantly associated with LVEF, E/e', GLS or LAEF. Age modified the association of CAC score with AoR; higher CAC scores were associated with larger AoR more strongly in older ( > 58 years; betaAoR0.0042;P < 0.007) than in younger ( < /=58 years) participants (betaAoR0.0027;P < 0.03). CONCLUSIONS: We observed that subclinical atherosclerosis was associated with ventricular and aortic remodeling. The prognostic significance of these associations warrants evaluation in additional mechanistic studies.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32413074&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright: © 2020 Castro-Diehl et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCoronary heart disease
dc.subjectBlood pressure
dc.subjectAtherosclerosis
dc.subjectHypertension
dc.subjectEchocardiography
dc.subjectLipids
dc.subjectPhysical activity
dc.subjectDiabetes mellitus
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectCirculatory and Respiratory Physiology
dc.subjectNutritional and Metabolic Diseases
dc.titleAssociation of subclinical atherosclerosis with echocardiographic indices of cardiac remodeling: The Framingham Study
dc.typeJournal Article
dc.source.journaltitlePloS one
dc.source.volume15
dc.source.issue5
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5286&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4260
dc.identifier.contextkey18226435
refterms.dateFOA2022-08-23T16:49:32Z
html.description.abstract<p>BACKGROUND: It is well established that coronary artery disease progresses along with myocardial disease. However, data on the association between coronary artery calcium (CAC) and echocardiographic variables are lacking.</p> <p>METHODS AND RESULTS: Among 2,650 Framingham Study participants (mean age 51 yrs, 48% women; 40% with CAC > 0), we related CT-based CAC score to left ventricular (LV) mass index (LVMi), LV ejection fraction (LVEF), E/e', global longitudinal strain (GLS), left atrial emptying fraction (LAEF), and aortic root diameter (AoR), using multivariable-adjusted generalized linear models. CAC score (independent variable) was used as log-transformed continuous [ln(CAC+1)] and as a categorical (0, 1-100, and > /=101) variable. Adjusting for standard risk factors, higher CAC score was associated with higher LVMi and AoR (betaLVMI per 1-SD increase 0.012, betaAoR 0.008; P < 0.05, for both). Participants with 1 < /=CAC < /=100 and those with CAC > /=101 had higher AoR (betaAoR 0.013 and 0.020, respectively, P = 0.01) than those with CAC = 0. CAC score was not significantly associated with LVEF, E/e', GLS or LAEF. Age modified the association of CAC score with AoR; higher CAC scores were associated with larger AoR more strongly in older ( > 58 years; betaAoR0.0042;P < 0.007) than in younger ( < /=58 years) participants (betaAoR0.0027;P < 0.03).</p> <p>CONCLUSIONS: We observed that subclinical atherosclerosis was associated with ventricular and aortic remodeling. The prognostic significance of these associations warrants evaluation in additional mechanistic studies.</p>
dc.identifier.submissionpathoapubs/4260
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pagese0233321


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Copyright: © 2020 Castro-Diehl et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright: © 2020 Castro-Diehl et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.