Defining trained immunity and its role in health and disease
| dc.contributor.author | Netea, Mihai G. | |
| dc.contributor.author | Latz, Eicke | |
| dc.date | 2022-08-11T08:09:56.000 | |
| dc.date.accessioned | 2022-08-23T16:49:36Z | |
| dc.date.available | 2022-08-23T16:49:36Z | |
| dc.date.issued | 2020-06-01 | |
| dc.date.submitted | 2020-07-09 | |
| dc.identifier.citation | <p>Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E. Defining trained immunity and its role in health and disease. Nat Rev Immunol. 2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4. PMID: 32132681; PMCID: PMC7186935. <a href="https://doi.org/10.1038/s41577-020-0285-6">Link to article on publisher's site</a></p> | |
| dc.identifier.issn | 1474-1733 (Linking) | |
| dc.identifier.doi | 10.1038/s41577-020-0285-6 | |
| dc.identifier.pmid | 32132681 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/41496 | |
| dc.description | <p>Full author list omitted for brevity. For the full list of authors, see article.</p> | |
| dc.description.abstract | Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed 'trained immunity', a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define 'trained immunity' as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32132681&dopt=Abstract">Link to Article in PubMed</a></p> | |
| dc.relation.url | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7186935/ | |
| dc.subject | Immunotherapy | |
| dc.subject | Infection | |
| dc.subject | Vaccines | |
| dc.subject | Immunity | |
| dc.subject | Immunology and Infectious Disease | |
| dc.subject | Immunology of Infectious Disease | |
| dc.subject | Immunopathology | |
| dc.title | Defining trained immunity and its role in health and disease | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Nature reviews. Immunology | |
| dc.source.volume | 20 | |
| dc.source.issue | 6 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/4276 | |
| dc.identifier.contextkey | 18456796 | |
| html.description.abstract | <p>Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed 'trained immunity', a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define 'trained immunity' as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.</p> | |
| dc.identifier.submissionpath | oapubs/4276 | |
| dc.contributor.department | Department of Medicine, Division of Infectious Diseases and Immunology | |
| dc.source.pages | 375-388 |