Machine Learning Model Based on Transthoracic Bioimpedance and Heart Rate Variability for Lung Fluid Accumulation Detection: Prospective Clinical Study
Authors
Reljin, NatasaPosada-Quintero, Hugo F.
Eaton-Robb, Caitlin
Binici, Sophia
Ensom, Emily
Ding, Eric Y.
Hayes, Anna
Riistama, Jarno
Darling, Chad E.
McManus, David D.
Chon, Ki H.
UMass Chan Affiliations
Graduate School of Biomedical SciencesDepartment of Emergency Medicine
Department of Medicine, Division of Cardiovascular Medicine
Document Type
Journal ArticlePublication Date
2020-08-27Keywords
autonomic nervous systemcardiology
fluid accumulation
heart failure
heart rate variability
machine learning
transthoracic bioimpedance
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Artificial Intelligence and Robotics
Bioinformatics
Biomedical Devices and Instrumentation
Cardiology
Cardiovascular Diseases
Metadata
Show full item recordAbstract
BACKGROUND: Accumulation of excess body fluid and autonomic dysregulation are clinically important characteristics of acute decompensated heart failure. We hypothesized that transthoracic bioimpedance, a noninvasive, simple method for measuring fluid retention in lungs, and heart rate variability, an assessment of autonomic function, can be used for detection of fluid accumulation in patients with acute decompensated heart failure. OBJECTIVE: We aimed to evaluate the performance of transthoracic bioimpedance and heart rate variability parameters obtained using a fluid accumulation vest with carbon black-polydimethylsiloxane dry electrodes in a prospective clinical study (System for Heart Failure Identification Using an External Lung Fluid Device; SHIELD). METHODS: We computed 15 parameters: 8 were calculated from the model to fit Cole-Cole plots from transthoracic bioimpedance measurements (extracellular, intracellular, intracellular-extracellular difference, and intracellular-extracellular parallel circuit resistances as well as fitting error, resonance frequency, tissue heterogeneity, and cellular membrane capacitance), and 7 were based on linear (mean heart rate, low-frequency components of heart rate variability, high-frequency components of heart rate variability, normalized low-frequency components of heart rate variability, normalized high-frequency components of heart rate variability) and nonlinear (principal dynamic mode index of sympathetic function, and principal dynamic mode index of parasympathetic function) analysis of heart rate variability. We compared the values of these parameters between 3 participant data sets: control (n=32, patients who did not have heart failure), baseline (n=23, patients with acute decompensated heart failure taken at the time of admittance to the hospital), and discharge (n=17, patients with acute decompensated heart failure taken at the time of discharge from hospital). We used several machine learning approaches to classify participants with fluid accumulation (baseline) and without fluid accumulation (control and discharge), termed with fluid and without fluid groups, respectively. RESULTS: Among the 15 parameters, 3 transthoracic bioimpedance (extracellular resistance, R0; difference in extracellular-intracellular resistance, R0 - Rinfinity, and tissue heterogeneity, alpha) and 3 heart rate variability (high-frequency, normalized low-frequency, and normalized high-frequency components) parameters were found to be the most discriminatory between groups (patients with and patients without heart failure). R0 and R0 - Rinfinity had significantly lower values for patients with heart failure than for those without heart failure (R0: P=.006; R0 - Rinfinity: P=.001), indicating that a higher volume of fluids accumulated in the lungs of patients with heart failure. A cubic support vector machine model using the 5 parameters achieved an accuracy of 92% for with fluid and without fluid group classification. The transthoracic bioimpedance parameters were related to intra- and extracellular fluid, whereas the heart rate variability parameters were mostly related to sympathetic activation. CONCLUSIONS: This is useful, for instance, for an in-home diagnostic wearable to detect fluid accumulation. Results suggest that fluid accumulation, and subsequently acute decompensated heart failure detection, could be performed using transthoracic bioimpedance and heart rate variability measurements acquired with a wearable vest. Emily Ensom, Eric Ding, Anna Hayes, Jarno Riistama, Chad Darling, David McManus, Ki H. Chon. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 27.08.2020.Source
Reljin N, Posada-Quintero HF, Eaton-Robb C, Binici S, Ensom E, Ding E, Hayes A, Riistama J, Darling C, McManus D, Chon KH. Machine Learning Model Based on Transthoracic Bioimpedance and Heart Rate Variability for Lung Fluid Accumulation Detection: Prospective Clinical Study. JMIR Med Inform. 2020 Aug 27;8(8):e18715. doi: 10.2196/18715. PMID: 32852277; PMCID: PMC7484776. Link to article on publisher's site
DOI
10.2196/18715Permanent Link to this Item
http://hdl.handle.net/20.500.14038/41542PubMed ID
32852277Related Resources
Rights
© Natasa Reljin, Hugo F. Posada-Quintero, Caitlin Eaton-Robb, Sophia Binici, Emily Ensom, Eric Ding, Anna Hayes, Jarno Riistama, Chad Darling, David McManus, Ki H. Chon. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 27.08.2020. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Informatics, is properly cited. The complete bibliographic information, a link to the original publication on http://medinform.jmir.org/, as well as this copyright and license information must be included.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.2196/18715
Scopus Count
Except where otherwise noted, this item's license is described as © Natasa Reljin, Hugo F. Posada-Quintero, Caitlin Eaton-Robb, Sophia Binici, Emily Ensom, Eric Ding, Anna Hayes, Jarno Riistama, Chad Darling, David McManus, Ki H. Chon. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 27.08.2020. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Informatics, is properly cited. The complete bibliographic information, a link to the original publication on http://medinform.jmir.org/, as well as this copyright and license information must be included.