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dc.contributor.authorAbu, Hawa Ozien
dc.contributor.authorSaczynski, Jane S.
dc.contributor.authorMehawej, Jordy
dc.contributor.authorTisminetzky, Mayra
dc.contributor.authorKiefe, Catarina I.
dc.contributor.authorGoldberg, Robert J.
dc.contributor.authorMcManus, David D.
dc.date2022-08-11T08:09:56.000
dc.date.accessioned2022-08-23T16:50:00Z
dc.date.available2022-08-23T16:50:00Z
dc.date.issued2020-09-15
dc.date.submitted2020-10-26
dc.identifier.citation<p>Abu HO, Saczynski JS, Mehawej J, Tisminetzky M, Kiefe CI, Goldberg RJ, McManus DD. Clinically Meaningful Change in Quality of Life and Associated Factors Among Older Patients With Atrial Fibrillation. J Am Heart Assoc. 2020 Sep 15;9(18):e016651. doi: 10.1161/JAHA.120.016651. Epub 2020 Sep 2. PMID: 32875941. <a href="https://doi.org/10.1161/JAHA.120.016651">Link to article on publisher's site</a></p>
dc.identifier.issn2047-9980 (Linking)
dc.identifier.doi10.1161/JAHA.120.016651
dc.identifier.pmid32875941
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41574
dc.description.abstractBackground: Among older patients with atrial fibrillation, there are limited data examining clinically meaningful changes in quality of life (QoL). We examined the extent of, and factors associated with, clinically meaningful change in QoL over 1-year among older adults with atrial fibrillation. Methods and Results: Patients from cardiology, electrophysiology, and primary care clinics in Massachusetts and Georgia were enrolled in a cohort study (2015-2018). The Atrial Fibrillation Effect on Quality-of-Life questionnaire was used to assess overall QoL and across 3 subscales: symptoms, daily activities, and treatment concern. Clinically meaningful change in QoL (ie, difference between 1-year and baseline QoL score) was categorized as either a decline ( < /=-5.0 points), no clinically meaningful change (-5.0 to +5.0 points), or an increase ( > /=+5.0 points). Ordinal logistic models were used to examine factors associated with QoL changes. Participants (n=1097) were on average 75 years old, 48% were women, and 87% White. Approximately 40% experienced a clinically meaningful increase in QoL and 1 in every 5 patients experienced a decline in QoL. After multivariable adjustment, women, non-Whites, those who reported depressive and anxiety symptoms, fair/poor self-rated health, low social support, heart failure, or diabetes mellitus experienced clinically meaningful declines in QoL. Conclusions: These findings provide insights to the magnitude of, and factors associated with, clinically meaningful change in QoL among older patients with atrial fibrillation. Assessment of comorbidities and psychosocial factors may help identify patients at high risk for declining QoL and those who require additional surveillance to maximize important clinical and patient-centered outcomes.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32875941&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectatrial fibrillation
dc.subjectelderly
dc.subjectquality of life
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectClinical Epidemiology
dc.subjectEpidemiology
dc.subjectGeriatrics
dc.titleClinically Meaningful Change in Quality of Life and Associated Factors Among Older Patients With Atrial Fibrillation
dc.typeJournal Article
dc.source.journaltitleJournal of the American Heart Association
dc.source.volume9
dc.source.issue18
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5392&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4364
dc.identifier.contextkey19982992
refterms.dateFOA2022-08-23T16:50:00Z
html.description.abstract<p>Background: Among older patients with atrial fibrillation, there are limited data examining clinically meaningful changes in quality of life (QoL). We examined the extent of, and factors associated with, clinically meaningful change in QoL over 1-year among older adults with atrial fibrillation.</p> <p>Methods and Results: Patients from cardiology, electrophysiology, and primary care clinics in Massachusetts and Georgia were enrolled in a cohort study (2015-2018). The Atrial Fibrillation Effect on Quality-of-Life questionnaire was used to assess overall QoL and across 3 subscales: symptoms, daily activities, and treatment concern. Clinically meaningful change in QoL (ie, difference between 1-year and baseline QoL score) was categorized as either a decline ( < /=-5.0 points), no clinically meaningful change (-5.0 to +5.0 points), or an increase ( > /=+5.0 points). Ordinal logistic models were used to examine factors associated with QoL changes. Participants (n=1097) were on average 75 years old, 48% were women, and 87% White. Approximately 40% experienced a clinically meaningful increase in QoL and 1 in every 5 patients experienced a decline in QoL. After multivariable adjustment, women, non-Whites, those who reported depressive and anxiety symptoms, fair/poor self-rated health, low social support, heart failure, or diabetes mellitus experienced clinically meaningful declines in QoL.</p> <p>Conclusions: These findings provide insights to the magnitude of, and factors associated with, clinically meaningful change in QoL among older patients with atrial fibrillation. Assessment of comorbidities and psychosocial factors may help identify patients at high risk for declining QoL and those who require additional surveillance to maximize important clinical and patient-centered outcomes.</p>
dc.identifier.submissionpathoapubs/4364
dc.contributor.departmentMeyers Primary Care Institute
dc.contributor.departmentDivision of Geriatrics, Department of Medicine
dc.contributor.departmentDivision of Cardiovascular Medicine, Department of Medicine
dc.source.pagese016651


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© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.  This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.