Network Meta-Analysis of Ulcerative Colitis Pharmacotherapies: Carryover Effects from Induction and Bias of the Results
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UMass Chan Affiliations
Department of Population and Quantitative Health SciencesDocument Type
Letter to the EditorPublication Date
2020-10-13Keywords
Ulcerative Colitistreatment
network meta-analyses
pharmacotherapies
Digestive System Diseases
Gastroenterology
Research Methods in Life Sciences
Therapeutics
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Dear Editor, In their network meta-analyses (NMAs) of treatments for ulcerative colitis (UC), Singh et al1 did not take into account a complication associated with studies that re-randomized patients for the maintenance phase: differential carryover effects from induction can bias the results. In those studies, patients who responded to induction were re-randomized to maintenance treatments that included placebo. If, however, carryover effects from induction differ substantially among active treatments, the effects of those treatments, relative to placebo, are not comparable.Source
Naessens D, Cameron C, Hoaglin DC. Network Meta-Analysis of Ulcerative Colitis Pharmacotherapies: Carryover Effects from Induction and Bias of the Results. Clin Gastroenterol Hepatol. 2020 Oct 13:S1542-3565(20)31428-2. doi: 10.1016/j.cgh.2020.10.016. Epub ahead of print. PMID: 33065309. Link to article on publisher's site
DOI
10.1016/j.cgh.2020.10.016Permanent Link to this Item
http://hdl.handle.net/20.500.14038/41609PubMed ID
33065309Related Resources
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© 2020 by the AGA Institute. This article is available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.cgh.2020.10.016
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Except where otherwise noted, this item's license is described as © 2020 by the AGA Institute. This article is available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.