A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux

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Authors
Allen, Elizabeth A.
Amato, Clelia
Fortier, Tina M.
Velentzas, Panagiotis D.
Wood, Will
Baehrecke, Eric H.
UMass Chan Affiliations
Department of Molecular, Cell, and Cancer Biology
Document Type
Journal Article
Publication Date
2020-11-02
Keywords
Cell death and autophagy
Development
Cell Biology
Cellular and Molecular Physiology
Developmental Biology
Enzymes and Coenzymes

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Abstract
Macroautophagy (autophagy) targets cytoplasmic cargoes to the lysosome for degradation. Like all vesicle trafficking, autophagy relies on phosphoinositide identity, concentration, and localization to execute multiple steps in this catabolic process. Here, we screen for phosphoinositide phosphatases that influence autophagy in Drosophila and identify CG3530. CG3530 is homologous to the human MTMR6 subfamily of myotubularin-related 3-phosphatases, and therefore, we named it dMtmr6. dMtmr6, which is required for development and viability in Drosophila, functions as a regulator of autophagic flux in multiple Drosophila cell types. The MTMR6 family member MTMR8 has a similar function in autophagy of higher animal cells. Decreased dMtmr6 and MTMR8 function results in autophagic vesicle accumulation and influences endolysosomal homeostasis.
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Allen EA, Amato C, Fortier TM, Velentzas P, Wood W, Baehrecke EH. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. J Cell Biol. 2020 Nov 2;219(11):e201909073. doi: 10.1083/jcb.201909073. PMID: 32915229; PMCID: PMC7594499. Link to article on publisher's site
DOI
10.1083/jcb.201909073
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/41673
PubMed ID
32915229
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© 2020 Allen et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
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© 2020 Allen et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
Except where otherwise noted, this item's license is described as © 2020 Allen et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).