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dc.contributor.authorLevit, Elle
dc.contributor.authorBouley, Andrew
dc.contributor.authorBaber, Ursela
dc.contributor.authorDjonlagic, Ina
dc.contributor.authorSloane, Jacob A.
dc.date2022-08-11T08:09:58.000
dc.date.accessioned2022-08-23T16:50:34Z
dc.date.available2022-08-23T16:50:34Z
dc.date.issued2020-11-05
dc.date.submitted2021-01-07
dc.identifier.citation<p>Levit E, Bouley A, Baber U, Djonlagic I, Sloane JA. Brainstem lesions are associated with sleep apnea in multiple sclerosis. Mult Scler J Exp Transl Clin. 2020 Nov 5;6(4):2055217320967955. doi: 10.1177/2055217320967955. PMID: 33224518; PMCID: PMC7649856. <a href="https://doi.org/10.1177/2055217320967955">Link to article on publisher's site</a></p>
dc.identifier.issn2055-2173 (Linking)
dc.identifier.doi10.1177/2055217320967955
dc.identifier.pmid33224518
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41683
dc.description.abstractBackground: Studies linking MRI findings in MS patients with obstructive sleep apnea severity are limited. Objective: We conducted a retrospective study to assess MRI abnormalities associated with obstructive sleep apnea (OSA) in patients with multiple sclerosis (MS). Methods: We performed retrospective chart review of 65 patients with multiple sclerosis who had undergone polysomnography (PSG) for fatigue as well as brain MRI. We measured the number of lesions in the brainstem and calculated the standardized third ventricular width (sTVW) as a measure of brain atrophy, and subsequently performed correlation analyses of the apnea-hypopnea index (AHI) with brainstem lesion location, sTVW, and Expanded Disability Status Scale (EDSS). Results: MS Patients with OSA were significantly older and had a higher body mass index (BMI) and higher AHI measures than patients without OSA. After adjustment for covariates, significant associations were found between AHI and lesion burden in the midbrain (p < 0.01) and pons (p = 0.05), but not medulla. Conclusions: Midbrain and pontine lesions burden correlated with AHI, suggesting MS lesion location could contribute to development of OSA.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=33224518&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © The Author(s) 2020. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectSleep apnea
dc.subjectapnea hypopnea index
dc.subjectatrophy
dc.subjectbrainstem
dc.subjectmultiple sclerosis
dc.subjectImmune System Diseases
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.subjectRespiratory Tract Diseases
dc.titleBrainstem lesions are associated with sleep apnea in multiple sclerosis
dc.typeJournal Article
dc.source.journaltitleMultiple sclerosis journal - experimental, translational and clinical
dc.source.volume6
dc.source.issue4
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5503&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4473
dc.identifier.contextkey20969184
refterms.dateFOA2022-08-23T16:50:34Z
html.description.abstract<p>Background: Studies linking MRI findings in MS patients with obstructive sleep apnea severity are limited.</p> <p>Objective: We conducted a retrospective study to assess MRI abnormalities associated with obstructive sleep apnea (OSA) in patients with multiple sclerosis (MS).</p> <p>Methods: We performed retrospective chart review of 65 patients with multiple sclerosis who had undergone polysomnography (PSG) for fatigue as well as brain MRI. We measured the number of lesions in the brainstem and calculated the standardized third ventricular width (sTVW) as a measure of brain atrophy, and subsequently performed correlation analyses of the apnea-hypopnea index (AHI) with brainstem lesion location, sTVW, and Expanded Disability Status Scale (EDSS).</p> <p>Results: MS Patients with OSA were significantly older and had a higher body mass index (BMI) and higher AHI measures than patients without OSA. After adjustment for covariates, significant associations were found between AHI and lesion burden in the midbrain (p < 0.01) and pons (p = 0.05), but not medulla.</p> <p>Conclusions: Midbrain and pontine lesions burden correlated with AHI, suggesting MS lesion location could contribute to development of OSA.</p>
dc.identifier.submissionpathoapubs/4473
dc.contributor.departmentDepartment of Neurology
dc.source.pages2055217320967955


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Copyright © The Author(s) 2020. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2020. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).