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dc.contributor.authorDos Santos, Luara Isabela
dc.contributor.authorTorres, Thais Abdala
dc.contributor.authorDiniz, Suelen Queiroz.
dc.contributor.authorGoncalves, Ricardo
dc.contributor.authorCaballero-Flores, Gustavo
dc.contributor.authorNunez, Gabriel
dc.contributor.authorGazzinelli, Ricardo T
dc.contributor.authorMaloy, Kevin Joseph.
dc.contributor.authorRibeiro do V Antonelli, Lis
dc.date2022-08-11T08:09:58.000
dc.date.accessioned2022-08-23T16:50:51Z
dc.date.available2022-08-23T16:50:51Z
dc.date.issued2021-01-12
dc.date.submitted2021-03-01
dc.identifier.citation<p>Dos Santos LI, Torres TA, Diniz SQ, Gonçalves R, Caballero-Flores G, Núñez G, Gazzinelli RT, Maloy KJ, Ribeiro do V Antonelli L. Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen. Cell Rep. 2021 Jan 12;34(2):108613. doi: 10.1016/j.celrep.2020.108613. PMID: 33440153. <a href="https://doi.org/10.1016/j.celrep.2020.108613">Link to article on publisher's site</a></p>
dc.identifier.issn2211-1247 (Electronic)
dc.identifier.doi10.1016/j.celrep.2020.108613
dc.identifier.pmid33440153
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41740
dc.description.abstractIndividuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr-) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr- bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality. Mortality in co-infected mice is associated with disrupted iron metabolism, elevated levels of plasma heme, and increased mitochondrial reactive oxygen species (ROS) production by phagocytes. In addition, iron acquisition by the bacterium plays a key role in pathogenesis because co-infection with a mutant C. rodentium strain lacking a critical iron acquisition pathway does not cause mortality. These results indicate that disrupted iron metabolism may drive mortality during co-infection with C. rodentium and P. chabaudi by both altering host immune responses and facilitating bacterial persistence.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=33440153&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright 2021 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCitrobacter rodentium
dc.subjectGram-negative bacteria
dc.subjectPlasmodium
dc.subjectco-infection
dc.subjectheme
dc.subjecthemolysis
dc.subjectiron
dc.subjectmalaria
dc.subjectmortality
dc.subjectBacterial Infections and Mycoses
dc.subjectImmunology of Infectious Disease
dc.subjectParasitic Diseases
dc.subjectPathogenic Microbiology
dc.titleDisrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
dc.typeJournal Article
dc.source.journaltitleCell reports
dc.source.volume34
dc.source.issue2
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5563&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4533
dc.identifier.contextkey21887762
refterms.dateFOA2022-08-23T16:50:51Z
html.description.abstract<p>Individuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr-) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr- bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality. Mortality in co-infected mice is associated with disrupted iron metabolism, elevated levels of plasma heme, and increased mitochondrial reactive oxygen species (ROS) production by phagocytes. In addition, iron acquisition by the bacterium plays a key role in pathogenesis because co-infection with a mutant C. rodentium strain lacking a critical iron acquisition pathway does not cause mortality. These results indicate that disrupted iron metabolism may drive mortality during co-infection with C. rodentium and P. chabaudi by both altering host immune responses and facilitating bacterial persistence.</p>
dc.identifier.submissionpathoapubs/4533
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages108613


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Copyright 2021 The Authors.  This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)
Except where otherwise noted, this item's license is described as Copyright 2021 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)