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dc.contributor.authorChoudhary, Khushal V.
dc.contributor.authorKakouros, Nikolaos
dc.contributor.authorAurigemma, Gerard P.
dc.contributor.authorParker, Matthew
dc.contributor.authorFitzgibbons, Timothy P
dc.date2022-08-11T08:09:59.000
dc.date.accessioned2022-08-23T16:51:17Z
dc.date.available2022-08-23T16:51:17Z
dc.date.issued2021-03-24
dc.date.submitted2021-06-08
dc.identifier.citation<p>Choudhary KV, Kakouros N, Aurigemma GP, Parker MW, Fitzgibbons T. Differentiating Pseudo Versus True Aortic Stenosis in Patients Without Contractile Reserve: A Diagnostic Dilemma. Cureus. 2021 Mar 24;13(3):e14086. doi: 10.7759/cureus.14086. PMID: 33903843; PMCID: PMC8064426. <a href="https://doi.org/10.7759/cureus.14086">Link to article on publisher's site</a></p>
dc.identifier.issn2168-8184 (Linking)
dc.identifier.doi10.7759/cureus.14086
dc.identifier.pmid33903843
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41829
dc.description.abstractLow-flow, low-gradient (LF-LG) aortic stenosis with depressed left ventricular (LV) ejection fraction is a diagnostic challenge that is frequently encountered in the management of valvular heart disease. True-severe LF-LG aortic stenosis is amenable to valve replacement, whereas pseudo-severe aortic stenosis requires management of the underlying cardiomyopathy. This distinction is important as it serves as a critical branch point in guiding therapeutic decisions. We present the case of a 71-year-old male with LF-LG aortic stenosis who had a reduced and biphasic augmentation of LV flow during dobutamine stress echocardiography (DSE). Further evaluation revealed a stenotic left subclavian artery proximal to the left internal mammary artery graft to the left anterior descending (LAD) artery. Bypass of the subclavian stenosis reversed the LAD territory ischemia and confirmed pseudo-severe aortic stenosis on repeat DSE. Traditional DSE parameters are inconclusive in patients with LF-LG aortic stenosis with poor flow reserve. Calculation of the projected orifice area or measurement of aortic valve calcium via multidetector computed tomography (MDCT) may be required in this scenario. Most importantly, reversible causes of LV dysfunction identified during DSE for LF-LG aortic stenosis require a different treatment approach than that of true aortic stenosis.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=33903843&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8064426/
dc.rightsCopyright © 2021, Choudhary et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectaortic stenosis
dc.subjectdobutamine
dc.subjectischemia
dc.subjectlow flow
dc.subjectlow gradient
dc.subjecttranscutaneous aortic valve replacement
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.titleDifferentiating Pseudo Versus True Aortic Stenosis in Patients Without Contractile Reserve: A Diagnostic Dilemma
dc.typeJournal Article
dc.source.journaltitleCureus
dc.source.volume13
dc.source.issue3
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5661&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4630
dc.identifier.contextkey23261638
refterms.dateFOA2022-08-23T16:51:18Z
html.description.abstract<p>Low-flow, low-gradient (LF-LG) aortic stenosis with depressed left ventricular (LV) ejection fraction is a diagnostic challenge that is frequently encountered in the management of valvular heart disease. True-severe LF-LG aortic stenosis is amenable to valve replacement, whereas pseudo-severe aortic stenosis requires management of the underlying cardiomyopathy. This distinction is important as it serves as a critical branch point in guiding therapeutic decisions. We present the case of a 71-year-old male with LF-LG aortic stenosis who had a reduced and biphasic augmentation of LV flow during dobutamine stress echocardiography (DSE). Further evaluation revealed a stenotic left subclavian artery proximal to the left internal mammary artery graft to the left anterior descending (LAD) artery. Bypass of the subclavian stenosis reversed the LAD territory ischemia and confirmed pseudo-severe aortic stenosis on repeat DSE. Traditional DSE parameters are inconclusive in patients with LF-LG aortic stenosis with poor flow reserve. Calculation of the projected orifice area or measurement of aortic valve calcium via multidetector computed tomography (MDCT) may be required in this scenario. Most importantly, reversible causes of LV dysfunction identified during DSE for LF-LG aortic stenosis require a different treatment approach than that of true aortic stenosis.</p>
dc.identifier.submissionpathoapubs/4630
dc.contributor.departmentDivision of Cardiovascular Medicine, Department of Medicine
dc.source.pagese14086


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Copyright © 2021, Choudhary et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright © 2021, Choudhary et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.