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    Emerging Immunotherapies in the Treatment of Brain Metastases

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    Authors
    Nieblas-Bedolla, Edwin
    Nayyar, Naema
    Singh, Mohini
    Sullivan, Ryan J.
    Brastianos, Priscilla K.
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences
    Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    2021-03-01
    Keywords
    Brain metastasis
    Immunotherapy
    Cancer Biology
    Immunotherapy
    Neoplasms
    Nervous System Diseases
    Oncology
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7930434/
    Abstract
    Brain metastases account for considerable morbidity and mortality in patients with cancer. Despite increasing prevalence, limited therapeutic options exist. Recent advances in our understanding of the molecular and cellular underpinnings of the tumor immune microenvironment and the immune evasive mechanisms employed by tumor cells have shed light on how immunotherapies may provide therapeutic benefit to patients. The development and evolution of immunotherapy continue to show promise for the treatment of brain metastases. Positive outcomes have been observed in several studies evaluating the efficacy and safety of these treatments. However, many challenges persist in the application of immunotherapies to brain metastases. This review discusses the potential benefits and challenges in the development and use of checkpoint inhibitors, chimeric antigen receptor T-cell therapy, and oncolytic viruses for the treatment of brain metastases. Future studies are necessary to further evaluate and assess the potential use of each of these therapies in this setting. As we gain more knowledge regarding the role immunotherapies may play in the treatment of brain metastases, it is important to consider how these treatments may guide clinical decision making for clinicians and the impact they may have on patients. IMPLICATIONS FOR PRACTICE: Immunotherapies have produced clinically significant outcomes in early clinical trials evaluating patients with brain metastases or demonstrated promising results in preclinical models. Checkpoint inhibitors have been the most common immunotherapy studied to date in the setting of brain metastases, but novel approaches that can harness the immune system to contain and eliminate cancer cells are currently under investigation and may soon become more common in the clinical setting. An understanding of these evolving therapies may be useful in determining how the future management and treatment of brain metastases among patients with cancer will continue to advance.
    Source

    Nieblas-Bedolla E, Nayyar N, Singh M, Sullivan RJ, Brastianos PK. Emerging Immunotherapies in the Treatment of Brain Metastases. Oncologist. 2021 Mar;26(3):231-241. doi: 10.1002/onco.13575. Epub 2020 Nov 10. PMID: 33103803; PMCID: PMC7930434. Link to article on publisher's site

    DOI
    10.1002/onco.13575
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/41850
    PubMed ID
    33103803
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    ae974a485f413a2113503eed53cd6c53
    10.1002/onco.13575
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