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Resident Memory T Cells in Autoimmune Skin Diseases

dc.contributor.authorRyan, Grace E.
dc.contributor.authorHarris, John E.
dc.contributor.authorRichmond, Jillian M.
dc.date2022-08-11T08:10:00.000
dc.date.accessioned2022-08-23T16:51:48Z
dc.date.available2022-08-23T16:51:48Z
dc.date.issued2021-05-03
dc.date.submitted2021-09-02
dc.identifier.citation<p>Ryan GE, Harris JE, Richmond JM. Resident Memory T Cells in Autoimmune Skin Diseases. Front Immunol. 2021 May 3;12:652191. doi: 10.3389/fimmu.2021.652191. PMID: 34012438; PMCID: PMC8128248. <a href="https://doi.org/10.3389/fimmu.2021.652191">Link to article on publisher's site</a></p>
dc.identifier.issn1664-3224 (Linking)
dc.identifier.doi10.3389/fimmu.2021.652191
dc.identifier.pmid34012438
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41926
dc.description.abstractTissue resident memory T cells (TRM) are a critical component of the immune system, providing the body with an immediate and highly specific response against pathogens re-infecting peripheral tissues. More recently, however, it has been demonstrated that TRM cells also form during autoimmunity. TRM mediated autoimmune diseases are particularly destructive, because unlike foreign antigens, the self-antigens are never cleared, continuously activating self-reactive TRM T cells. In this article, we will focus on how TRMs mediate disease in autoimmune skin conditions, specifically vitiligo, psoriasis, cutaneous lupus erythematosus, alopecia areata and frontal fibrosing alopecia.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34012438&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2021 Ryan, Harris and Richmond. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectalopecia
dc.subjectautoimmunity
dc.subjectcutaneous lupus erythematosus (CLE)
dc.subjectdermatology
dc.subjectpsoriasis
dc.subjectresident memory T cell (TRM)
dc.subjectvitiligo
dc.subjectDermatology
dc.subjectImmune System Diseases
dc.subjectImmunity
dc.subjectSkin and Connective Tissue Diseases
dc.titleResident Memory T Cells in Autoimmune Skin Diseases
dc.typeJournal Article
dc.source.journaltitleFrontiers in immunology
dc.source.volume12
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5764&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4731
dc.identifier.contextkey24636132
refterms.dateFOA2022-08-23T16:51:48Z
html.description.abstract<p>Tissue resident memory T cells (TRM) are a critical component of the immune system, providing the body with an immediate and highly specific response against pathogens re-infecting peripheral tissues. More recently, however, it has been demonstrated that TRM cells also form during autoimmunity. TRM mediated autoimmune diseases are particularly destructive, because unlike foreign antigens, the self-antigens are never cleared, continuously activating self-reactive TRM T cells. In this article, we will focus on how TRMs mediate disease in autoimmune skin conditions, specifically vitiligo, psoriasis, cutaneous lupus erythematosus, alopecia areata and frontal fibrosing alopecia.</p>
dc.identifier.submissionpathoapubs/4731
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentDepartment of Dermatology
dc.source.pages652191


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Copyright © 2021 Ryan, Harris and Richmond. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as Copyright © 2021 Ryan, Harris and Richmond. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.