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dc.contributor.authorJung, Roy
dc.contributor.authorPalleti Janardhan, Harish
dc.contributor.authorDresser, Karen A.
dc.contributor.authorCotton, Jennifer L.
dc.contributor.authorHutchinson, Lloyd
dc.contributor.authorMao, Junhao
dc.contributor.authorTrivedi, Chinmay M.
dc.date2022-08-11T08:10:00.000
dc.date.accessioned2022-08-23T16:51:59Z
dc.date.available2022-08-23T16:51:59Z
dc.date.issued2021-07-01
dc.date.submitted2021-10-19
dc.identifier.citation<p>Jung R, Janardhan HP, Dresser K, Cotton JL, Hutchinson L, Mao J, Trivedi CM. Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma. Arterioscler Thromb Vasc Biol. 2021 Jul;41(7):2233-2235. doi: 10.1161/ATVBAHA.121.316300. Epub 2021 Jun 3. PMID: 34078092; PMCID: PMC8216595. <a href="https://doi.org/10.1161/ATVBAHA.121.316300">Link to article on publisher's site</a></p>
dc.identifier.issn1079-5642 (Linking)
dc.identifier.doi10.1161/ATVBAHA.121.316300
dc.identifier.pmid34078092
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41963
dc.description.abstractEpithelioid hemangioendothelioma, first described in early 1980s,is a rare malignant vascular neoplasm with significant morbidity and mortality. Approximately 50% of epithelioid hemangioendotheliomas exhibit intravascular endothelial growth, yet their cellular origin, pathogenesis, and effective treatment remain undefined. Here, we identified stable nuclear expression of endothelial YAP1 (Yes1-associated transcriptional regulator) in pathological tissue samples from patients with epithelioid hemangioendothelioma. Mice expressing stable nuclear form of YAP1 in endothelial cells recapitulated the human intravascular epithelioid hemangioendothelioma phenotype. Sustained YAP1 activity induced mitosis and aberrant expression of lymphatic and epithelioid genes in blood endothelial cells. These results show sustained activation of endothelial YAP1 as a causal mechanism for intravascular epithelioid hemangioendothelioma.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34078092&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2021 The Authors. Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectheart neoplasms
dc.subjectmorbidity
dc.subjectneoplasms
dc.subjectsarcoma
dc.subjectvascular diseases
dc.subjectCardiovascular Diseases
dc.subjectNeoplasms
dc.subjectPathology
dc.titleSustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma
dc.typeJournal Article
dc.source.journaltitleArteriosclerosis, thrombosis, and vascular biology
dc.source.volume41
dc.source.issue7
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5800&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4767
dc.identifier.contextkey25501382
refterms.dateFOA2022-08-23T16:51:59Z
html.description.abstract<p>Epithelioid hemangioendothelioma, first described in early 1980s,is a rare malignant vascular neoplasm with significant morbidity and mortality. Approximately 50% of epithelioid hemangioendotheliomas exhibit intravascular endothelial growth, yet their cellular origin, pathogenesis, and effective treatment remain undefined. Here, we identified stable nuclear expression of endothelial YAP1 (Yes1-associated transcriptional regulator) in pathological tissue samples from patients with epithelioid hemangioendothelioma. Mice expressing stable nuclear form of YAP1 in endothelial cells recapitulated the human intravascular epithelioid hemangioendothelioma phenotype. Sustained YAP1 activity induced mitosis and aberrant expression of lymphatic and epithelioid genes in blood endothelial cells. These results show sustained activation of endothelial YAP1 as a causal mechanism for intravascular epithelioid hemangioendothelioma.</p>
dc.identifier.submissionpathoapubs/4767
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.contributor.departmentLi-Weibo Institute for Rare Diseases Research
dc.contributor.departmentDepartment of Molecular, Cell, and Cancer Biology
dc.contributor.departmentDepartment of Pathology
dc.contributor.departmentDivision of Cardiovascular Medicine, Department of Medicine
dc.source.pages2233-2235


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Copyright © 2021 The Authors. Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as Copyright © 2021 The Authors. Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.