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dc.contributor.authorAretz, Benjamin
dc.contributor.authorJanssen, Fanny
dc.contributor.authorVonk, Judith M.
dc.contributor.authorHeneka, Michael T
dc.contributor.authorBoezen, H. Marike
dc.contributor.authorDoblhammer, Gabriele
dc.date2022-08-11T08:10:00.000
dc.date.accessioned2022-08-23T16:52:02Z
dc.date.available2022-08-23T16:52:02Z
dc.date.issued2021-10-01
dc.date.submitted2021-10-19
dc.identifier.citation<p>Aretz B, Janssen F, Vonk JM, Heneka MT, Boezen HM, Doblhammer G. Long-term exposure to fine particulate matter, lung function and cognitive performance: A prospective Dutch cohort study on the underlying routes. Environ Res. 2021 Oct;201:111533. doi: 10.1016/j.envres.2021.111533. Epub 2021 Jun 18. PMID: 34153335. <a href="https://doi.org/10.1016/j.envres.2021.111533">Link to article on publisher's site</a></p>
dc.identifier.issn0013-9351 (Linking)
dc.identifier.doi10.1016/j.envres.2021.111533
dc.identifier.pmid34153335
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41972
dc.description.abstractBACKGROUND: Exposure to fine particulate matter and black carbon is related to cognitive impairment and poor lung function, but less is known about the routes taken by different types of air pollutants to affect cognition. OBJECTIVES: We tested two possible routes of fine particulate matter (PM2.5) and black carbon (BC) in impairing cognition, and evaluated their importance: a direct route over the olfactory nerve or the blood stream, and an indirect route over the lung. METHODS: We used longitudinal observational data for 49,705 people aged 18+ from 2006 to 2015 from the Dutch Lifelines cohort study. By linking current home addresses to air pollution exposure data from ELAPSE in 2010, long-term average exposure to PM2.5 and BC was assessed. Lung function was measured by spirometry and Global Initiative (GLI) z-scores of forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) were calculated. Cognitive performance was measured by cognitive processing time (CPT) assessed by the Cogstate Brief Battery. Linear structural equation modeling was performed to test direct/indirect associations. RESULTS: Higher exposure to PM2.5 but not BC was related to higher CPT and slower cognitive processing speed [Total Effect PM2.5: FEV1 model = 8.31 x 10(-3) (95% CI: 5.71 x 10(-3), 10.91 x 10(-3)), FVC model = 8.30 x 10(-3) (95% CI: 5.69 x 10(-3), 10.90 x 10(-3))]. The direct association of PM2.5 constituted more than 97% of the total effect. Mediation by lung function was low for PM2.5 with a mediated proportion of 1.32% (FEV1) and 2.05% (FVC), but higher for BC (7.01% and 13.82% respectively). DISCUSSION: Our results emphasise the importance of the lung acting as a mediator in the relationship between both exposure to PM2.5 and BC, and cognitive performance. However, higher exposure to PM2.5 was mainly directly associated with worse cognitive performance, which emphasises the health-relevance of fine particles due to their ability to reach vital organs directly.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34153335&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights© 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBlack carbon
dc.subjectCognitive performance
dc.subjectFine particulate matter
dc.subjectLung function
dc.subjectMediation analysis
dc.subjectPathways
dc.subjectEnvironmental Public Health
dc.titleLong-term exposure to fine particulate matter, lung function and cognitive performance: A prospective Dutch cohort study on the underlying routes
dc.typeJournal Article
dc.source.journaltitleEnvironmental research
dc.source.volume201
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5809&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4776
dc.identifier.contextkey25501391
refterms.dateFOA2022-08-23T16:52:02Z
html.description.abstract<p>BACKGROUND: Exposure to fine particulate matter and black carbon is related to cognitive impairment and poor lung function, but less is known about the routes taken by different types of air pollutants to affect cognition.</p> <p>OBJECTIVES: We tested two possible routes of fine particulate matter (PM2.5) and black carbon (BC) in impairing cognition, and evaluated their importance: a direct route over the olfactory nerve or the blood stream, and an indirect route over the lung.</p> <p>METHODS: We used longitudinal observational data for 49,705 people aged 18+ from 2006 to 2015 from the Dutch Lifelines cohort study. By linking current home addresses to air pollution exposure data from ELAPSE in 2010, long-term average exposure to PM2.5 and BC was assessed. Lung function was measured by spirometry and Global Initiative (GLI) z-scores of forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) were calculated. Cognitive performance was measured by cognitive processing time (CPT) assessed by the Cogstate Brief Battery. Linear structural equation modeling was performed to test direct/indirect associations.</p> <p>RESULTS: Higher exposure to PM2.5 but not BC was related to higher CPT and slower cognitive processing speed [Total Effect PM2.5: FEV1 model = 8.31 x 10(-3) (95% CI: 5.71 x 10(-3), 10.91 x 10(-3)), FVC model = 8.30 x 10(-3) (95% CI: 5.69 x 10(-3), 10.90 x 10(-3))]. The direct association of PM2.5 constituted more than 97% of the total effect. Mediation by lung function was low for PM2.5 with a mediated proportion of 1.32% (FEV1) and 2.05% (FVC), but higher for BC (7.01% and 13.82% respectively).</p> <p>DISCUSSION: Our results emphasise the importance of the lung acting as a mediator in the relationship between both exposure to PM2.5 and BC, and cognitive performance. However, higher exposure to PM2.5 was mainly directly associated with worse cognitive performance, which emphasises the health-relevance of fine particles due to their ability to reach vital organs directly.</p>
dc.identifier.submissionpathoapubs/4776
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages111533


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© 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).