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dc.contributor.authorSeneschal, Julien
dc.contributor.authorHarris, John E.
dc.contributor.authorLe Poole, I. Caroline
dc.contributor.authorPasseron, Thierry
dc.contributor.authorSpeeckaert, Reinhart
dc.contributor.authorBoniface, Katia
dc.date2022-08-11T08:10:00.000
dc.date.accessioned2022-08-23T16:52:02Z
dc.date.available2022-08-23T16:52:02Z
dc.date.issued2021-06-24
dc.date.submitted2021-10-27
dc.identifier.citation<p>Seneschal J, Harris JE, Le Poole IC, Passeron T, Speeckaert R, Boniface K. Editorial: Immunology of Vitiligo. Front Immunol. 2021 Jun 24;12:711080. doi: 10.3389/fimmu.2021.711080. PMID: 34249018; PMCID: PMC8264751. <a href="https://doi.org/10.3389/fimmu.2021.711080">Link to article on publisher's site</a></p>
dc.identifier.issn1664-3224 (Linking)
dc.identifier.doi10.3389/fimmu.2021.711080
dc.identifier.pmid34249018
dc.identifier.urihttp://hdl.handle.net/20.500.14038/41975
dc.description.abstractDisappearance of melanocytes is the pathogenic hallmark of vitiligo. Progressive depigmentation of the skin has a high negative impact on patients’ quality of life. To date, vitiligo remains a therapeutic challenge. Several theories have been proposed to explain disease pathogenesis, considering the roles of increased inflammatory and cytotoxic immune responses, neuropeptides, microvascular anomalies, intrinsic abnormalities in melanocyte and keratinocyte adhesion, as well as oxidative stress. Over the past decades, clinical, basic, and translational research on patient samples as well as in vitro and in vivo models have tremendously improved our understanding of the pathophysiology of the disease and highlighted its complexity. Such progress is of utmost importance to identify appropriate therapeutic targets and treatments to halt progression of the disease and to induce repigmentation. “Immunology of vitiligo” is a collection of six review articles and four original articles focusing on complementary aspects of the immune pathways involved in vitiligo, from a pathophysiologic to a therapeutic perspective.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34249018&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2021 Seneschal, Harris, Le Poole, Passeron, Speeckaert and Boniface. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectadaptive immunity
dc.subjectinnate immunity
dc.subjectmelanocytes
dc.subjectoxidative stress
dc.subjecttolerance
dc.subjecttranslational research
dc.subjectvitiligo
dc.subjectDermatology
dc.subjectImmunity
dc.subjectImmunopathology
dc.subjectMedical Immunology
dc.subjectSkin and Connective Tissue Diseases
dc.titleEditorial: Immunology of Vitiligo
dc.typeEditorial
dc.source.journaltitleFrontiers in immunology
dc.source.volume12
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5812&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4779
dc.identifier.contextkey25625665
refterms.dateFOA2022-08-23T16:52:03Z
html.description.abstract<p><p id="x-x-__p3">Disappearance of melanocytes is the pathogenic hallmark of vitiligo. Progressive depigmentation of the skin has a high negative impact on patients’ quality of life. To date, vitiligo remains a therapeutic challenge. <p id="x-x-__p4">Several theories have been proposed to explain disease pathogenesis, considering the roles of increased inflammatory and cytotoxic immune responses, neuropeptides, microvascular anomalies, intrinsic abnormalities in melanocyte and keratinocyte adhesion, as well as oxidative stress. Over the past decades, clinical, basic, and translational research on patient samples as well as <em>in vitro</em> and <em>in vivo</em> models have tremendously improved our understanding of the pathophysiology of the disease and highlighted its complexity. Such progress is of utmost importance to identify appropriate therapeutic targets and treatments to halt progression of the disease and to induce repigmentation. “Immunology of vitiligo” is a collection of six review articles and four original articles focusing on complementary aspects of the immune pathways involved in vitiligo, from a pathophysiologic to a therapeutic perspective.</p>
dc.identifier.submissionpathoapubs/4779
dc.contributor.departmentDepartment of Dermatology
dc.source.pages711080


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Copyright © 2021 Seneschal, Harris, Le Poole, Passeron, Speeckaert and Boniface. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as Copyright © 2021 Seneschal, Harris, Le Poole, Passeron, Speeckaert and Boniface. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.