Show simple item record

dc.contributor.authorWang, Hsuan-Yuan
dc.contributor.authorValencia, Sarah M.
dc.contributor.authorPfeifer, Susanne P.
dc.contributor.authorJensen, Jeffrey D.
dc.contributor.authorKowalik, Timothy F.
dc.contributor.authorPermar, Sallie R.
dc.date2022-08-11T08:10:01.000
dc.date.accessioned2022-08-23T16:52:15Z
dc.date.available2022-08-23T16:52:15Z
dc.date.issued2021-06-09
dc.date.submitted2021-12-14
dc.identifier.citation<p>Wang HY, Valencia SM, Pfeifer SP, Jensen JD, Kowalik TF, Permar SR. Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity. Viruses. 2021 Jun 9;13(6):1106. doi: 10.3390/v13061106. PMID: 34207868; PMCID: PMC8227702. <a href="https://doi.org/10.3390/v13061106">Link to article on publisher's site</a></p>
dc.identifier.issn1999-4915 (Linking)
dc.identifier.doi10.3390/v13061106
dc.identifier.pmid34207868
dc.identifier.urihttp://hdl.handle.net/20.500.14038/42016
dc.description.abstractHuman cytomegalovirus (HCMV), one of the most prevalent viruses across the globe, is a common cause of morbidity and mortality for immunocompromised individuals. Recent clinical observations have demonstrated that mixed strain infections are common and may lead to more severe disease progression. This clinical observation illustrates the complexity of the HCMV genome and emphasizes the importance of taking a population-level view of genotypic evolution. Here we review frequently sampled polymorphisms in the glycoproteins of HCMV, comparing the variable regions, and summarizing their corresponding geographic distributions observed to date. The related strain-specific immunity, including neutralization activity and antigen-specific cellular immunity, is also discussed. Given that these glycoproteins are common targets for vaccine design and anti-viral therapies, this observed genetic variation represents an important resource for future efforts to combat HCMV infections.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34207868&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectgenotype
dc.subjectglycoprotein
dc.subjecthuman cytomegalovirus
dc.subjectpolymorphism
dc.subjectstrain-specific immunity
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectGenetics and Genomics
dc.subjectImmunology of Infectious Disease
dc.subjectPopulation Biology
dc.subjectVirology
dc.subjectViruses
dc.titleCommon Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity
dc.typeJournal Article
dc.source.journaltitleViruses
dc.source.volume13
dc.source.issue6
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5852&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4819
dc.identifier.contextkey26839333
refterms.dateFOA2022-08-23T16:52:15Z
html.description.abstract<p>Human cytomegalovirus (HCMV), one of the most prevalent viruses across the globe, is a common cause of morbidity and mortality for immunocompromised individuals. Recent clinical observations have demonstrated that mixed strain infections are common and may lead to more severe disease progression. This clinical observation illustrates the complexity of the HCMV genome and emphasizes the importance of taking a population-level view of genotypic evolution. Here we review frequently sampled polymorphisms in the glycoproteins of HCMV, comparing the variable regions, and summarizing their corresponding geographic distributions observed to date. The related strain-specific immunity, including neutralization activity and antigen-specific cellular immunity, is also discussed. Given that these glycoproteins are common targets for vaccine design and anti-viral therapies, this observed genetic variation represents an important resource for future efforts to combat HCMV infections.</p>
dc.identifier.submissionpathoapubs/4819
dc.contributor.departmentDepartment of Microbiology and Physiological Systems
dc.source.pages1106


Files in this item

Thumbnail
Name:
viruses_13_01106.pdf
Size:
3.839Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).