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    TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking

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    Authors
    Lu, Yubing
    Almeida, Sandra
    Gao, Fen-Biao
    UMass Chan Affiliations
    Department of Neurology
    Document Type
    Journal Article
    Publication Date
    2021-07-01
    Keywords
    ALS
    FTD
    Membrane trafficking
    Neurons
    TBK 1
    iPSC
    Neuroscience and Neurobiology
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500533/
    Abstract
    TANK-binding kinase 1 (TBK1) haploinsufficiency causes both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 is an IKK-related serine/threonine kinase and primarily known for its involvement in inflammation and autophagy. In particular, TBK1 phosphorylates several autophagy adaptor proteins, including SQSTM1/p62, optineurin, and NDP52. However, other phosphorylation substrates of TBK1 are largely unknown.
    Source

    Lu Y, Almeida S, Gao FB. TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking. Acta Neuropathol. 2021 Jul;142(1):217-221. doi: 10.1007/s00401-021-02331-1. Epub 2021 Jun 3. PMID: 34081168; PMCID: PMC8500533. Link to article on publisher's site

    DOI
    10.1007/s00401-021-02331-1
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/42018
    PubMed ID
    34081168
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1007/s00401-021-02331-1
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