TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking
UMass Chan AffiliationsDepartment of Neurology
Document TypeJournal Article
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AbstractTANK-binding kinase 1 (TBK1) haploinsufficiency causes both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 is an IKK-related serine/threonine kinase and primarily known for its involvement in inflammation and autophagy. In particular, TBK1 phosphorylates several autophagy adaptor proteins, including SQSTM1/p62, optineurin, and NDP52. However, other phosphorylation substrates of TBK1 are largely unknown.
Lu Y, Almeida S, Gao FB. TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking. Acta Neuropathol. 2021 Jul;142(1):217-221. doi: 10.1007/s00401-021-02331-1. Epub 2021 Jun 3. PMID: 34081168; PMCID: PMC8500533. Link to article on publisher's site