TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking
UMass Chan Affiliations
Department of NeurologyDocument Type
Journal ArticlePublication Date
2021-07-01
Metadata
Show full item recordAbstract
TANK-binding kinase 1 (TBK1) haploinsufficiency causes both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 is an IKK-related serine/threonine kinase and primarily known for its involvement in inflammation and autophagy. In particular, TBK1 phosphorylates several autophagy adaptor proteins, including SQSTM1/p62, optineurin, and NDP52. However, other phosphorylation substrates of TBK1 are largely unknown.Source
Lu Y, Almeida S, Gao FB. TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking. Acta Neuropathol. 2021 Jul;142(1):217-221. doi: 10.1007/s00401-021-02331-1. Epub 2021 Jun 3. PMID: 34081168; PMCID: PMC8500533. Link to article on publisher's site
DOI
10.1007/s00401-021-02331-1Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42018PubMed ID
34081168Related Resources
ae974a485f413a2113503eed53cd6c53
10.1007/s00401-021-02331-1