TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking

Authors
Lu, Yubing
Almeida, Sandra
Gao, Fen-Biao
UMass Chan Affiliations
Department of Neurology
Document Type
Journal Article
Publication Date
2021-07-01
Keywords
ALS
FTD
Membrane trafficking
Neurons
TBK 1
iPSC
Neuroscience and Neurobiology

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Link to Full Text
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500533/
Abstract
TANK-binding kinase 1 (TBK1) haploinsufficiency causes both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 is an IKK-related serine/threonine kinase and primarily known for its involvement in inflammation and autophagy. In particular, TBK1 phosphorylates several autophagy adaptor proteins, including SQSTM1/p62, optineurin, and NDP52. However, other phosphorylation substrates of TBK1 are largely unknown.
Source

Lu Y, Almeida S, Gao FB. TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking. Acta Neuropathol. 2021 Jul;142(1):217-221. doi: 10.1007/s00401-021-02331-1. Epub 2021 Jun 3. PMID: 34081168; PMCID: PMC8500533. Link to article on publisher's site
DOI
10.1007/s00401-021-02331-1
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42018
PubMed ID
34081168
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