TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking
| dc.contributor.author | Lu, Yubing | |
| dc.contributor.author | Almeida, Sandra | |
| dc.contributor.author | Gao, Fen-Biao | |
| dc.date | 2022-08-11T08:10:01.000 | |
| dc.date.accessioned | 2022-08-23T16:52:16Z | |
| dc.date.available | 2022-08-23T16:52:16Z | |
| dc.date.issued | 2021-07-01 | |
| dc.date.submitted | 2022-01-02 | |
| dc.identifier.citation | <p>Lu Y, Almeida S, Gao FB. TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking. Acta Neuropathol. 2021 Jul;142(1):217-221. doi: 10.1007/s00401-021-02331-1. Epub 2021 Jun 3. PMID: 34081168; PMCID: PMC8500533. <a href="https://doi.org/10.1007/s00401-021-02331-1">Link to article on publisher's site</a></p> | |
| dc.identifier.issn | 0001-6322 (Linking) | |
| dc.identifier.doi | 10.1007/s00401-021-02331-1 | |
| dc.identifier.pmid | 34081168 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/42018 | |
| dc.description.abstract | TANK-binding kinase 1 (TBK1) haploinsufficiency causes both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 is an IKK-related serine/threonine kinase and primarily known for its involvement in inflammation and autophagy. In particular, TBK1 phosphorylates several autophagy adaptor proteins, including SQSTM1/p62, optineurin, and NDP52. However, other phosphorylation substrates of TBK1 are largely unknown. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34081168&dopt=Abstract">Link to Article in PubMed</a></p> | |
| dc.relation.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500533/ | |
| dc.subject | ALS | |
| dc.subject | FTD | |
| dc.subject | Membrane trafficking | |
| dc.subject | Neurons | |
| dc.subject | TBK 1 | |
| dc.subject | iPSC | |
| dc.subject | Neuroscience and Neurobiology | |
| dc.title | TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Acta neuropathologica | |
| dc.source.volume | 142 | |
| dc.source.issue | 1 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/4820 | |
| dc.identifier.contextkey | 27074131 | |
| html.description.abstract | <p>TANK-binding kinase 1 (<em>TBK1</em>) haploinsufficiency causes both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 is an IKK-related serine/threonine kinase and primarily known for its involvement in inflammation and autophagy. In particular, TBK1 phosphorylates several autophagy adaptor proteins, including SQSTM1/p62, optineurin, and NDP52. However, other phosphorylation substrates of TBK1 are largely unknown.</p> | |
| dc.identifier.submissionpath | oapubs/4820 | |
| dc.contributor.department | Department of Neurology | |
| dc.source.pages | 217-221 |