Neutralizing antibodies against Epstein-Barr virus infection of B cells can protect from oral viral challenge in the rhesus macaque animal model
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Authors
Muhe, JanineAye, Pyone Pyone
Quink, Carol
Eng, Jing Ying
Engelman, Kathleen D.
Reimann, Keith A.
Wang, Fred
UMass Chan Affiliations
MassBiologicsDocument Type
Journal ArticlePublication Date
2021-07-20Keywords
72A1E1D1
EBV vaccine
Epstein-Barr virus
lymphocryptovirus
Immunology and Infectious Disease
Virus Diseases
Viruses
Metadata
Show full item recordAbstract
Epstein-Barr virus (EBV) and related lymphocryptoviruses (LCVs) from nonhuman primates are transmitted through oral secretions, penetrate the mucosal epithelium, and establish persistent infection in B cells. To determine whether neutralizing antibodies against epithelial or B cell infection could block oral transmission and persistent LCV infection, we use rhesus macaques, the most accurate animal model for EBV infection by faithfully reproducing acute and persistent infection in humans. Naive animals are infused with monoclonal antibodies neutralizing epithelial cell infection or B cell infection and then challenged orally with recombinant rhesus LCV. Our data show that high-titer B cell-neutralizing antibodies alone, but not epithelial cell-neutralizing antibodies, can provide complete protection of rhesus macaques from oral LCV challenge, but not in all hosts. Thus, neutralizing antibodies against B cell infection are important targets for EBV vaccine development, but they may not be sufficient.Source
Mühe J, Aye PP, Quink C, Eng JY, Engelman K, Reimann KA, Wang F. Neutralizing antibodies against Epstein-Barr virus infection of B cells can protect from oral viral challenge in the rhesus macaque animal model. Cell Rep Med. 2021 Jul 21;2(7):100352. doi: 10.1016/j.xcrm.2021.100352. PMID: 34337567; PMCID: PMC8324488. Link to article on publisher's site
DOI
10.1016/j.xcrm.2021.100352Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42024PubMed ID
34337567Related Resources
Rights
Copyright © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.xcrm.2021.100352
Scopus Count
Collections
Except where otherwise noted, this item's license is described as Copyright © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).