Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed
Authors
Raghav, AlokTripathi, Prashant
Mishra, Brijesh Kumar
Jeong, Goo-Bo
Banday, Shahid
Gautam, Kirti Amresh
Mateen, Qazi Noorul
Singh, Prem
Singh, Manish
Singla, Akhil
Ahmad, Jamal
UMass Chan Affiliations
Department of Molecular, Cell and Cancer BiologyDocument Type
Journal ArticlePublication Date
2021-07-27Keywords
bacterial infectioncustomized exosomes
diabetes foot ulcers
diabetes mellitus
exosomes
Bacterial Infections and Mycoses
Endocrine System Diseases
Microbiology
Molecular, Cellular, and Tissue Engineering
Nutritional and Metabolic Diseases
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Exosomes are nano-vesicles of endosomal origin inherited with characteristics of drug delivery and cargo loading. Exosomes offer a diverse range of opportunities that can be exploited in the treatment of various diseases post-functionalization. This membrane engineering is recently being used in the management of bacteria-associated diabetic foot ulcers (DFUs). Diabetes mellitus (DM) is among the most crippling disease of society with a large share of its imposing economic burden. DM in a chronic state is associated with the development of micro- and macrovascular complications. DFU is among the diabetic microvascular complications with the consequent occurrence of diabetic peripheral neuropathy. Mesenchymal stromal cell (MSC)-derived exosomes post-tailoring hold promise to accelerate the diabetic wound repair in DFU associated with bacterial inhabitant. These exosomes promote the antibacterial properties with regenerative activity by loading bioactive molecules like growth factors, nucleic acids, and proteins, and non-bioactive substances like antibiotics. Functionalization of MSC-derived exosomes is mediated by various physical, chemical, and biological processes that effectively load the desired cargo into the exosomes for targeted delivery at specific bacterial DFUs and wound. The present study focused on the application of the cargo-loaded exosomes in the treatment of DFU and also emphasizes the different approaches for loading the desired cargo/drug inside exosomes. However, more studies and clinical trials are needed in the domain to explore this membrane engineering.Source
Raghav A, Tripathi P, Mishra BK, Jeong GB, Banday S, Gautam KA, Mateen QN, Singh P, Singh M, Singla A, Ahmad J. Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed. Front Microbiol. 2021 Jul 27;12:712588. doi: 10.3389/fmicb.2021.712588. PMID: 34385994; PMCID: PMC8354005. Link to article on publisher's site
DOI
10.3389/fmicb.2021.712588Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42033PubMed ID
34385994Related Resources
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Copyright © 2021 Raghav, Tripathi, Mishra, Jeong, Banday, Gautam, Mateen, Singh, Singh, Singla and Ahmad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.3389/fmicb.2021.712588
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Except where otherwise noted, this item's license is described as Copyright © 2021 Raghav, Tripathi, Mishra, Jeong, Banday, Gautam, Mateen, Singh, Singh, Singla and Ahmad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.