Associations of HDL metrics with coronary artery calcium score and density among women traversing menopause
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Authors
El Khoudary, Samar R.Nasr, Alexis
Matthews, Karen A.
Orchard, Trevor J.
Brooks, Maria M.
Billheimer, Jeffrey
McConnell, Dan
Janssen, Imke
Everson-Rose, Susan A.
Crawford, Sybil L.
Rader, Daniel J.
UMass Chan Affiliations
Department of MedicineDocument Type
Journal ArticlePublication Date
2021-07-22Keywords
HDL/structurecalcium density
calcium score
cardiovascular disease
cholesterol/Efflux
climacteric
hormones
lipoproteins
menopause
women
Amino Acids, Peptides, and Proteins
Biological Factors
Cardiovascular Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Lipids
Reproductive and Urinary Physiology
Women's Health
Metadata
Show full item recordAbstract
The cardioprotective association of high-density lipoprotein cholesterol (HDL-C) may vary by menopause stage or estradiol level. We tested whether associations of comprehensive HDL metrics (HDL subclasses, phospholipid and triglyceride content, and HDL cholesterol efflux capacity [HDL-CEC]) with coronary artery calcium (CAC) score and density vary by menopause stage or estradiol level in women transitioning through menopause. Participants (N = 294; mean age [SD]: 51.3 [2.9]) had data on HDL metrics and CAC measures at one or two time points during the menopause transition. Generalized estimating equations were used for analyses. Effect modifications by menopause stage or estradiol level were tested in multivariable models. In adjusted models, menopause stage modified the associations of specific HDL metrics with CAC measures. Higher small HDL particles (HDL-P) concentrations (p-interaction = 0.008) and smaller HDL size (p-interaction = 0.02) were associated with greater odds of CAC presence in late perimenopause than in pre/early perimenopause stage. Women in the highest estradiol tertile, but not the lower tertiles, showed a protective association of small HDL-P with CAC presence (p-interaction = 0.007). Lower large HDL-P concentrations (p-interaction = 0.03) and smaller HDL size (p-interaction = 0.03) were associated with lower CAC density in late perimenopause than in postmenopause stage. Associations of HDL phospholipid and triglyceride content and HDL-CEC with CAC measures did not vary by menopause stage or estradiol level. We concluded that HDL subclasses may impact the likelihood of CAC presence and the stability of coronary plaque differently over the menopause transition. Endogenous estradiol levels may contribute to this observation.Source
El Khoudary SR, Nasr A, Matthews KA, Orchard TJ, Brooks MM, Billheimer J, McConnell D, Janssen I, Everson-Rose SA, Crawford S, Rader DJ. Associations of HDL metrics with coronary artery calcium score and density among women traversing menopause. J Lipid Res. 2021;62:100098. doi: 10.1016/j.jlr.2021.100098. Epub 2021 Jul 22. PMID: 34303684; PMCID: PMC8385165. Link to article on publisher's site
DOI
10.1016/j.jlr.2021.100098Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42042PubMed ID
34303684Related Resources
Rights
Copyright © 2021 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.jlr.2021.100098
Scopus Count
Collections
Except where otherwise noted, this item's license is described as Copyright © 2021 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).