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Autophagy in major human diseases

dc.contributor.authorKlionsky, Daniel J.
dc.contributor.authorBaehrecke, Eric H.
dc.contributor.authorGalluzzi, Lorenzo
dc.contributor.authorPietrocola, Federico
dc.date2022-08-11T08:10:01.000
dc.date.accessioned2022-08-23T16:52:35Z
dc.date.available2022-08-23T16:52:35Z
dc.date.issued2021-10-01
dc.date.submitted2022-02-28
dc.identifier.citation<p>Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez-Otin C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F. Autophagy in major human diseases. EMBO J. 2021 Oct 1;40(19):e108863. doi: 10.15252/embj.2021108863. Epub 2021 Aug 30. PMID: 34459017; PMCID: PMC8488577. <a href="https://doi.org/10.15252/embj.2021108863">Link to article on publisher's site</a></p>
dc.identifier.issn0261-4189 (Linking)
dc.identifier.doi10.15252/embj.2021108863
dc.identifier.pmid34459017
dc.identifier.urihttp://hdl.handle.net/20.500.14038/42082
dc.description<p>Full author list omitted for brevity. For the full list of authors, see article.</p>
dc.description.abstractAutophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34459017&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2021 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectaging
dc.subjectcancer
dc.subjectinflammation
dc.subjectmetabolic syndromes
dc.subjectneurodegeneration
dc.subjectBiological Phenomena, Cell Phenomena, and Immunity
dc.subjectCell Biology
dc.subjectCellular and Molecular Physiology
dc.titleAutophagy in major human diseases
dc.typeJournal Article
dc.source.journaltitleThe EMBO journal
dc.source.volume40
dc.source.issue19
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5919&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4885
dc.identifier.contextkey28282627
refterms.dateFOA2022-08-23T16:52:35Z
html.description.abstract<p>Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.</p>
dc.identifier.submissionpathoapubs/4885
dc.contributor.departmentDepartment of Molecular, Cell and Cancer Biology
dc.source.pagese108863


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Copyright © 2021 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright © 2021 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.