Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice
Authors
Dohi, TakehikoSalz, Whitney
Costa, Marco R.
Ariyan, Charlotte
Basadonna, Giacomo P.
Altieri, Dario C.
Document Type
Journal ArticlePublication Date
2006-02-14Keywords
Animals*Apoptosis
Cell Line
Diabetes Mellitus
Gene Expression Regulation
Humans
Islets of Langerhans
*Islets of Langerhans Transplantation
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microtubule-Associated Proteins
Neoplasm Proteins
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Survivin is a cancer gene implicated in inhibition of apoptosis and regulation of mitosis, but its function in normal cells has remained elusive. Here, we show that transgenic mice expressing survivin in pancreatic islet beta-cells show no changes in cell proliferation, as determined by islet size or islet number. Transplantation of survivin transgenic islets in diabetic recipient mice affords long-term engraftment and stable correction of hyperglycaemia. This involves intrinsic inhibition of beta-cell apoptosis, in vivo, and global transcriptional changes in pancreatic islets with upregulation of stress response genes, antagonists of cytokine signalling and promoters of angiogenesis. These broad cytoprotective functions of survivin in vivo might be beneficial for gene therapy of diabetes.Source
EMBO Rep. 2006 Apr;7(4):438-43. Epub 2006 Feb 10. Link to article on publisher's site
DOI
10.1038/sj.embor.7400640Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42133PubMed ID
16470228Related Resources
ae974a485f413a2113503eed53cd6c53
10.1038/sj.embor.7400640