Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice
Costa, Marco R.
Basadonna, Giacomo P.
Altieri, Dario C.
Gene Expression Regulation
Islets of Langerhans
*Islets of Langerhans Transplantation
Mice, Inbred C57BL
Medicine and Health Sciences
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AbstractSurvivin is a cancer gene implicated in inhibition of apoptosis and regulation of mitosis, but its function in normal cells has remained elusive. Here, we show that transgenic mice expressing survivin in pancreatic islet beta-cells show no changes in cell proliferation, as determined by islet size or islet number. Transplantation of survivin transgenic islets in diabetic recipient mice affords long-term engraftment and stable correction of hyperglycaemia. This involves intrinsic inhibition of beta-cell apoptosis, in vivo, and global transcriptional changes in pancreatic islets with upregulation of stress response genes, antagonists of cytokine signalling and promoters of angiogenesis. These broad cytoprotective functions of survivin in vivo might be beneficial for gene therapy of diabetes.
EMBO Rep. 2006 Apr;7(4):438-43. Epub 2006 Feb 10. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/42133