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    Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice

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    Authors
    Dohi, Takehiko
    Salz, Whitney
    Costa, Marco R.
    Ariyan, Charlotte
    Basadonna, Giacomo P.
    Altieri, Dario C.
    UMass Chan Affiliations
    Department of Surgery
    Department of Cancer Biology
    Document Type
    Journal Article
    Publication Date
    2006-02-14
    Keywords
    Animals
    *Apoptosis
    Cell Line
    Diabetes Mellitus
    Gene Expression Regulation
    Humans
    Islets of Langerhans
    *Islets of Langerhans Transplantation
    Mice
    Mice, Inbred C57BL
    Mice, Transgenic
    Microtubule-Associated Proteins
    Neoplasm Proteins
    Life Sciences
    Medicine and Health Sciences
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456913/
    Abstract
    Survivin is a cancer gene implicated in inhibition of apoptosis and regulation of mitosis, but its function in normal cells has remained elusive. Here, we show that transgenic mice expressing survivin in pancreatic islet beta-cells show no changes in cell proliferation, as determined by islet size or islet number. Transplantation of survivin transgenic islets in diabetic recipient mice affords long-term engraftment and stable correction of hyperglycaemia. This involves intrinsic inhibition of beta-cell apoptosis, in vivo, and global transcriptional changes in pancreatic islets with upregulation of stress response genes, antagonists of cytokine signalling and promoters of angiogenesis. These broad cytoprotective functions of survivin in vivo might be beneficial for gene therapy of diabetes.
    Source

    EMBO Rep. 2006 Apr;7(4):438-43. Epub 2006 Feb 10. Link to article on publisher's site

    DOI
    10.1038/sj.embor.7400640
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/42133
    PubMed ID
    16470228
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.embor.7400640
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