The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53
| dc.contributor.author | Teodoro, Jose G. | |
| dc.contributor.author | Heilman, Destin W. | |
| dc.contributor.author | Parker, Albert E | |
| dc.contributor.author | Green, Michael R. | |
| dc.date | 2022-08-11T08:10:02.000 | |
| dc.date.accessioned | 2022-08-23T16:53:09Z | |
| dc.date.available | 2022-08-23T16:53:09Z | |
| dc.date.issued | 2004-08-18 | |
| dc.date.submitted | 2008-07-15 | |
| dc.identifier.citation | <p>Genes Dev. 2004 Aug 15;18(16):1952-7. <a href="http://dx.doi.org/10.1101/gad.1198404">Link to article on publisher's site</a></p> | |
| dc.identifier.issn | 0890-9369 (Print) | |
| dc.identifier.doi | 10.1101/gad.1198404 | |
| dc.identifier.pmid | 15314021 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/42210 | |
| dc.description.abstract | The chicken anemia virus protein Apoptin induces apoptosis in the absence of p53 by a mechanism that remains to be elucidated. Here we show that in transformed cells, Apoptin is associated with APC1, a subunit of the anaphase-promoting complex/cyclosome (APC/C). We demonstrate that Apoptin expression, or depletion of APC1 by RNA interference, inhibits APC/C function in p53 null cells, resulting in G2/M arrest and apoptosis. Our results explain the ability of Apoptin to induce apoptosis in the absence of p53 and suggest that the APC/C is an attractive target for anticancer drug development. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15314021&dopt=Abstract">Link to Article in PubMed</a></p> | |
| dc.relation.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514174/ | |
| dc.subject | Apoptosis | |
| dc.subject | Base Sequence | |
| dc.subject | Capsid Proteins | |
| dc.subject | DNA Primers | |
| dc.subject | Fluorescent Antibody Technique | |
| dc.subject | G2 Phase | |
| dc.subject | Humans | |
| dc.subject | Mitosis | |
| dc.subject | Precipitin Tests | |
| dc.subject | Protein Binding | |
| dc.subject | Tumor Suppressor Protein p53 | |
| dc.subject | Ubiquitin-Protein Ligase Complexes | |
| dc.subject | Life Sciences | |
| dc.subject | Medicine and Health Sciences | |
| dc.title | The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53 | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Genes and development | |
| dc.source.volume | 18 | |
| dc.source.issue | 16 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/578 | |
| dc.identifier.contextkey | 549007 | |
| html.description.abstract | <p>The chicken anemia virus protein Apoptin induces apoptosis in the absence of p53 by a mechanism that remains to be elucidated. Here we show that in transformed cells, Apoptin is associated with APC1, a subunit of the anaphase-promoting complex/cyclosome (APC/C). We demonstrate that Apoptin expression, or depletion of APC1 by RNA interference, inhibits APC/C function in p53 null cells, resulting in G2/M arrest and apoptosis. Our results explain the ability of Apoptin to induce apoptosis in the absence of p53 and suggest that the APC/C is an attractive target for anticancer drug development.</p> | |
| dc.identifier.submissionpath | oapubs/578 | |
| dc.contributor.department | Program in Gene Function and Expression | |
| dc.contributor.department | Program in Molecular Medicine | |
| dc.contributor.department | Howard Hughes Medical Institute | |
| dc.source.pages | 1952-7 |
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