A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
1996-02-01Keywords
AdolescentAged
Amino Acid Sequence
Animals
Base Sequence
Child, Preschool
Drosophila
Female
Hela Cells
HumansLeukemia, Lymphocytic, Chronic, B-CellMaleMitogensMolecular Sequence DataMolecular WeightNuclear ProteinsPhosphorylationPrecursor Cell Lymphoblastic Leukemia-LymphomaProtein-Serine-Threonine KinasespurificationRecombinant Fusion ProteinsSequence AnalysisSequence Homology, Amino AcidSignal TransductionSubstrate SpecificitySignal transductionkinasesDrosophilaleukemiatrithorax]BiochemistryCell BiologyDevelopmental BiologyMolecular Biology
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Show full item recordAbstract
Although the ultimate targets of many signal transduction pathways are nuclear transcription factors, the vast majority of known protein kinases are cytosolic. Here, we report on a novel human kinase that is present exclusively in the nucleus. Kinase activity is increased upon cellular proliferation and is markedly elevated in patients with acute and chronic lymphocytic leukemias. We have identified a human gene that encodes this nuclear kinase and find that it is closely related to Drosophila female sterile homeotic (fsh), a developmental regulator with no known biochemical activity. Collectively, these results suggest that this nuclear kinase is a component of a signal transduction pathway that plays a role in Drosophila development and human growth control.Source
Genes Dev. 1996 Feb 1;10(3):261-71. Link to article on publisher's site
DOI
10.1101/gad.10.3.261Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42232PubMed ID
8595877Related Resources
Rights
© 1996 by Cold Spring Harbor Laboratory Press. Publisher PDF posted as allowed by the publisher's license to publish at https://genome.cshlp.org/site/misc/GR_LicenseToPublish_2014_v4.pdf.Scopus Count
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