A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator
UMass Chan AffiliationsProgram in Molecular Medicine
Amino Acid Sequence
Leukemia, Lymphocytic, Chronic, B-Cell
Molecular Sequence Data
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recombinant Fusion Proteins
Sequence Homology, Amino Acid
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AbstractAlthough the ultimate targets of many signal transduction pathways are nuclear transcription factors, the vast majority of known protein kinases are cytosolic. Here, we report on a novel human kinase that is present exclusively in the nucleus. Kinase activity is increased upon cellular proliferation and is markedly elevated in patients with acute and chronic lymphocytic leukemias. We have identified a human gene that encodes this nuclear kinase and find that it is closely related to Drosophila female sterile homeotic (fsh), a developmental regulator with no known biochemical activity. Collectively, these results suggest that this nuclear kinase is a component of a signal transduction pathway that plays a role in Drosophila development and human growth control.
Genes Dev. 1996 Feb 1;10(3):261-71. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/42232
Rights© 1996 by Cold Spring Harbor Laboratory Press. Publisher PDF posted as allowed by the publisher's license to publish at https://genome.cshlp.org/site/misc/GR_LicenseToPublish_2014_v4.pdf.
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