Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton
| dc.contributor.author | Okamoto, Patricia M. | |
| dc.contributor.author | Gamby, Chantal | |
| dc.contributor.author | Wells, David G. | |
| dc.contributor.author | Fallon, Justin R. | |
| dc.contributor.author | Vallee, Richard B. | |
| dc.date | 2022-08-11T08:10:03.000 | |
| dc.date.accessioned | 2022-08-23T16:53:54Z | |
| dc.date.available | 2022-08-23T16:53:54Z | |
| dc.date.issued | 2001-10-05 | |
| dc.date.submitted | 2008-08-04 | |
| dc.identifier.citation | <p>J Biol Chem. 2001 Dec 21;276(51):48458-65. Epub 2001 Oct 2. <a href="http://dx.doi.org/10.1074/jbc.M104927200">Link to article on publisher's site</a></p> | |
| dc.identifier.issn | 0021-9258 (Print) | |
| dc.identifier.doi | 10.1074/jbc.M104927200 | |
| dc.identifier.pmid | 11583995 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/42381 | |
| dc.description.abstract | Dynamin is a GTPase involved in endocytosis and other aspects of membrane trafficking. A critical function in the presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synaptic vesicle recycling. We report that dynamin-2 specifically interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and present evidence that dynamin-2 is specifically associated with the postsynaptic density. These data are consistent with a role for this otherwise broadly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynaptic membrane turnover. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=11583995&dopt=Abstract">Link to Article in PubMed</a></p> | |
| dc.relation.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715172/ | |
| dc.subject | Actins | |
| dc.subject | *Adaptor Proteins, Signal Transducing | |
| dc.subject | Amino Acid Sequence | |
| dc.subject | Animals | |
| dc.subject | COS Cells | |
| dc.subject | Carrier Proteins | |
| dc.subject | Cloning, Molecular | |
| dc.subject | Dynamin I | |
| dc.subject | Dynamins | |
| dc.subject | GTP Phosphohydrolases | |
| dc.subject | Nerve Tissue Proteins | |
| dc.subject | Precipitin Tests | |
| dc.subject | Protein Binding | |
| dc.subject | Protein Isoforms | |
| dc.subject | Synapses | |
| dc.subject | Two-Hybrid System Techniques | |
| dc.subject | Life Sciences | |
| dc.subject | Medicine and Health Sciences | |
| dc.title | Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton | |
| dc.type | Journal Article | |
| dc.source.journaltitle | The Journal of biological chemistry | |
| dc.source.volume | 276 | |
| dc.source.issue | 51 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/735 | |
| dc.identifier.contextkey | 564650 | |
| html.description.abstract | <p>Dynamin is a GTPase involved in endocytosis and other aspects of membrane trafficking. A critical function in the presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synaptic vesicle recycling. We report that dynamin-2 specifically interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and present evidence that dynamin-2 is specifically associated with the postsynaptic density. These data are consistent with a role for this otherwise broadly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynaptic membrane turnover.</p> | |
| dc.identifier.submissionpath | oapubs/735 | |
| dc.contributor.department | Department of Cell Biology | |
| dc.source.pages | 48458-65 |
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