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dc.contributor.authorTavakoli-Nezhad, Mahboubeh
dc.contributor.authorSchwartz, William J.
dc.date2022-08-11T08:10:05.000
dc.date.accessioned2022-08-23T16:54:44Z
dc.date.available2022-08-23T16:54:44Z
dc.date.issued2005-11-04
dc.date.submitted2008-08-15
dc.identifier.citation<p>J Biol Rhythms. 2005 Oct;20(5):419-29. <a href="http://dx.doi.org/10.1177/0748730405278443">Link to article on publisher's site</a></p>
dc.identifier.issn0748-7304 (Print)
dc.identifier.doi10.1177/0748730405278443
dc.identifier.pmid16267381
dc.identifier.urihttp://hdl.handle.net/20.500.14038/42571
dc.description.abstract"Splitting" of circadian activity rhythms in Syrian hamsters maintained in constant light appears to be the consequence of a reorganized SCN, with left and right halves oscillating in antiphase; in split hamsters, high mRNA levels characteristic of day and night are simultaneously expressed on opposite sides of the paired SCN. To visualize the splitting phenomenon at a cellular level, immunohistochemical c-Fos protein expression in the SCN and brains of split hamsters was analyzed. One side of the split SCN exhibited relatively high c-Fos levels, in a pattern resembling that seen in normal, unsplit hamsters during subjective day in constant darkness; the opposite side was labeled only within a central-dorsolateral area of the caudal SCN, in a region that likely coincides with a photo-responsive, glutamate receptor antagonist-insensitive, pERK-expressing cluster of cells previously identified by other laboratories. Outside the SCN, visual inspection revealed an obvious left-right asymmetry of c-Fos expression in the medial preoptic nucleus and subparaventricular zone of split hamsters killed during the inactive phase and in the medial division of the lateral habenula during the active phase (when the hamsters were running in their wheels). Roles for the dorsolateral SCN and the mediolateral habenula in circadian timekeeping are not yet understood.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16267381&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380273/
dc.subjectAnimals
dc.subjectCircadian Rhythm
dc.subjectCricetinae
dc.subjectDarkness
dc.subject*Habenula
dc.subject*Light
dc.subjectMale
dc.subjectMesocricetus
dc.subjectMotor Activity
dc.subjectNuclear Proteins
dc.subjectPhotoperiod
dc.subjectProto-Oncogene Proteins c-fos
dc.subject*Suprachiasmatic Nucleus
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titlec-Fos expression in the brains of behaviorally "split" hamsters in constant light: calling attention to a dorsolateral region of the suprachiasmatic nucleus and the medial division of the lateral habenula
dc.typeJournal Article
dc.source.journaltitleJournal of biological rhythms
dc.source.volume20
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/907
dc.identifier.contextkey579796
html.description.abstract<p>"Splitting" of circadian activity rhythms in Syrian hamsters maintained in constant light appears to be the consequence of a reorganized SCN, with left and right halves oscillating in antiphase; in split hamsters, high mRNA levels characteristic of day and night are simultaneously expressed on opposite sides of the paired SCN. To visualize the splitting phenomenon at a cellular level, immunohistochemical c-Fos protein expression in the SCN and brains of split hamsters was analyzed. One side of the split SCN exhibited relatively high c-Fos levels, in a pattern resembling that seen in normal, unsplit hamsters during subjective day in constant darkness; the opposite side was labeled only within a central-dorsolateral area of the caudal SCN, in a region that likely coincides with a photo-responsive, glutamate receptor antagonist-insensitive, pERK-expressing cluster of cells previously identified by other laboratories. Outside the SCN, visual inspection revealed an obvious left-right asymmetry of c-Fos expression in the medial preoptic nucleus and subparaventricular zone of split hamsters killed during the inactive phase and in the medial division of the lateral habenula during the active phase (when the hamsters were running in their wheels). Roles for the dorsolateral SCN and the mediolateral habenula in circadian timekeeping are not yet understood.</p>
dc.identifier.submissionpathoapubs/907
dc.contributor.departmentDepartment of Neurology
dc.source.pages419-29


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