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    Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice

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    Authors
    Szomolanyi-Tsuda, Eva
    Dundon, Patricia L.
    Joris, Isabelle
    Shultz, Leonard D.
    Woda, Bruce A.
    Welsh, R M
    UMass Chan Affiliations
    Department of Pathology
    Document Type
    Journal Article
    Publication Date
    1994-02-01
    Keywords
    Acute Disease
    Animals
    DNA, Viral
    Female
    Histocompatibility Antigens
    Killer Cells, Natural
    Male
    Mice
    Mice, Inbred C57BL
    Mice, SCID
    Myeloproliferative Disorders
    *Polyomavirus
    Polyomavirus Infections
    Severe Combined Immunodeficiency
    Tumor Virus Infections
    Life Sciences
    Medicine and Health Sciences
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887132/?tool=pubmed
    Abstract
    Infection of severe combined immunodeficient mice, which lack T and B lymphocytes, with polyomavirus (PyV) induced an acute hematological disorder leading to the death of the mice by 2 weeks postinfection. The disease was characterized by a dramatic decrease in megakaryocytes, multiple hemorrhages, anemia, thrombocytopenia, splenomegaly, a massive myeloproliferation and splenic erythroproliferation with a defect in maturation of the myeloid elements similar to that in acute leukemia. This pathology in severe combined immunodeficient mice is very different from that of the well-characterized tumor profiles induced by PyV in normal newborn or nude mice. Viral T and capsid (VP1) antigens and viral genome were detected in some cells in the spleen, but not in the majority of the proliferating myeloid cells. This suggests that the myeloproliferation is induced by some indirect mechanism, such as secretion of growth factors or cytokines by virus-infected cells, rather than by direct transformation by PyV. Neither the spread of PyV, its replication in different organs, nor the pathogenesis or the time of death were altered by depleting natural killer cells in vivo by anti-natural killer cell antibodies. Analysis of the spleen leukocyte population indicated that the cells expressed high levels of class I major histocompatibility complex antigens and were resistant to lysis by activated natural killer cells.
    Source
    Am J Pathol. 1994 Feb;144(2):359-71.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/42629
    PubMed ID
    8311119
    Related Resources
    Link to article in PubMed
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    UMass Chan Faculty and Researcher Publications

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