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dc.contributor.authorZand, Thomas
dc.contributor.authorMajno, G.
dc.contributor.authorNunnari, John J.
dc.contributor.authorHoffman, Allen H.
dc.contributor.authorSavilonis, Brian J.
dc.contributor.authorMacWilliams, Bruce
dc.contributor.authorJoris, Isabelle
dc.date2022-08-11T08:10:05.000
dc.date.accessioned2022-08-23T16:55:08Z
dc.date.available2022-08-23T16:55:08Z
dc.date.issued1991-07-01
dc.date.submitted2007-12-10
dc.identifier.citationAm J Pathol. 1991 Jul;139(1):101-13.
dc.identifier.issn0002-9440 (Print)
dc.identifier.pmid1853927
dc.identifier.urihttp://hdl.handle.net/20.500.14038/42651
dc.description.abstractThese experiments were designed to study the topography of lipid deposition in the stenotic aorta of hypercholesterolemic rats, and to correlate it with flow conditions and intimal stresses and strains studied in a scale biophysical model and in a computer model. A 69% +/- 5% stenosis was produced with a U-shaped metal clip. One month to 8 months later, the aorta was studied en face by light microscopy after fixation and lipid staining. The intima in the throat of the stenosis was almost completely free of lipid, whereas symmetric lipid deposits occurred as bands just above and especially just below the stenosis; elsewhere lipid deposits appeared to be random. The flow data obtained from the scale model showed that the intima in the throat of the stenosis was subjected to an increase of as much as 20 times in shear stress, whereas the lipid deposits just above and just below the stenosis were associated with asymmetric flow conditions: the proximal area corresponded to a region of rapidly increasing shear stress, the distal area to a region of low to normal shear stress and separated flow. A finite element computer model based on the aortic deformations indicated that the endothelium at the inlet and outlet of the stenosis is subjected to a symmetric pattern of elevated stresses and strains. These results indicate that 1) the pattern of lipid deposition can not be adequately explained by a hypothesis based solely on flow conditions, and 2) lipid deposits can develop in areas of increased fluid shear stress, decreased fluid shear stress, and increased intimal strains.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1853927&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886145/?tool=pubmed
dc.subjectAnimals
dc.subjectAorta
dc.subjectAortic Valve Stenosis
dc.subjectHypercholesterolemia
dc.subject*Lipid Metabolism
dc.subjectMale
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectRegional Blood Flow
dc.subjectStress, Mechanical
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleLipid deposition and intimal stress and strain. A study in rats with aortic stenosis
dc.typeJournal Article
dc.source.journaltitleThe American journal of pathology
dc.source.volume139
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/98
dc.identifier.contextkey403157
html.description.abstract<p>These experiments were designed to study the topography of lipid deposition in the stenotic aorta of hypercholesterolemic rats, and to correlate it with flow conditions and intimal stresses and strains studied in a scale biophysical model and in a computer model. A 69% +/- 5% stenosis was produced with a U-shaped metal clip. One month to 8 months later, the aorta was studied en face by light microscopy after fixation and lipid staining. The intima in the throat of the stenosis was almost completely free of lipid, whereas symmetric lipid deposits occurred as bands just above and especially just below the stenosis; elsewhere lipid deposits appeared to be random. The flow data obtained from the scale model showed that the intima in the throat of the stenosis was subjected to an increase of as much as 20 times in shear stress, whereas the lipid deposits just above and just below the stenosis were associated with asymmetric flow conditions: the proximal area corresponded to a region of rapidly increasing shear stress, the distal area to a region of low to normal shear stress and separated flow. A finite element computer model based on the aortic deformations indicated that the endothelium at the inlet and outlet of the stenosis is subjected to a symmetric pattern of elevated stresses and strains. These results indicate that 1) the pattern of lipid deposition can not be adequately explained by a hypothesis based solely on flow conditions, and 2) lipid deposits can develop in areas of increased fluid shear stress, decreased fluid shear stress, and increased intimal strains.</p>
dc.identifier.submissionpathoapubs/98
dc.contributor.departmentDepartment of Pathology
dc.source.pages101-13


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