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    Judging a virus by its cover

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    Authors
    Szomolanyi-Tsuda, Eva
    Welsh, Raymond M.
    UMass Chan Affiliations
    Department of Molecular Genetics and Microbiology
    Department of Pathology
    Document Type
    Journal Article
    Publication Date
    2004-10-07
    Keywords
    Animals
    Antibodies, Viral
    Humans
    Membrane Glycoproteins
    Mice
    Neutralization Tests
    RNA, Viral
    Viral Envelope Proteins
    Virion
    Medical Pathology
    Microbiology
    Molecular Genetics
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    Abstract
    The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.
    Source
    J Clin Invest. 2004 Oct;114(7):895-7. Link to article on publisher's site
    DOI
    10.1172/JCI23098
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/42670
    PubMed ID
    15467827
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1172/JCI23098
    Scopus Count
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    UMass Chan Faculty and Researcher Publications

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