Judging a virus by its cover
| dc.contributor.author | Szomolanyi-Tsuda, Eva | |
| dc.contributor.author | Welsh, Raymond M. | |
| dc.date | 2022-08-11T08:10:05.000 | |
| dc.date.accessioned | 2022-08-23T16:55:13Z | |
| dc.date.available | 2022-08-23T16:55:13Z | |
| dc.date.issued | 2004-10-07 | |
| dc.date.submitted | 2008-10-31 | |
| dc.identifier.citation | J Clin Invest. 2004 Oct;114(7):895-7. <a href="http://dx.doi.org/10.1172/JCI23098">Link to article on publisher's site</a> | |
| dc.identifier.issn | 0021-9738 (Print) | |
| dc.identifier.doi | 10.1172/JCI23098 | |
| dc.identifier.pmid | 15467827 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/42670 | |
| dc.description.abstract | The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15467827&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.subject | Animals | |
| dc.subject | Antibodies, Viral | |
| dc.subject | Humans | |
| dc.subject | Membrane Glycoproteins | |
| dc.subject | Mice | |
| dc.subject | Neutralization Tests | |
| dc.subject | RNA, Viral | |
| dc.subject | Viral Envelope Proteins | |
| dc.subject | Virion | |
| dc.subject | Medical Pathology | |
| dc.subject | Microbiology | |
| dc.subject | Molecular Genetics | |
| dc.title | Judging a virus by its cover | |
| dc.type | Journal Article | |
| dc.source.journaltitle | The Journal of clinical investigation | |
| dc.source.volume | 114 | |
| dc.source.issue | 7 | |
| dc.identifier.legacyfulltext | https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1996&context=oapubs&unstamped=1 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/997 | |
| dc.identifier.contextkey | 659180 | |
| refterms.dateFOA | 2022-08-23T16:55:13Z | |
| html.description.abstract | <p>The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.</p> | |
| dc.identifier.submissionpath | oapubs/997 | |
| dc.contributor.department | Department of Molecular Genetics and Microbiology | |
| dc.contributor.department | Department of Pathology | |
| dc.source.pages | 895-7 |
