Dengue: defining protective versus pathologic immunity
| dc.contributor.author | Rothman, Alan L. | |
| dc.date | 2022-08-11T08:10:05.000 | |
| dc.date.accessioned | 2022-08-23T16:55:13Z | |
| dc.date.available | 2022-08-23T16:55:13Z | |
| dc.date.issued | 2004-04-02 | |
| dc.date.submitted | 2008-10-31 | |
| dc.identifier.citation | J Clin Invest. 2004 Apr;113(7):946-51. <a href="http://dx.doi.org/10.1172/JCI21512">Link to article on publisher's site</a> | |
| dc.identifier.issn | 0021-9738 (Print) | |
| dc.identifier.doi | 10.1172/JCI21512 | |
| dc.identifier.pmid | 15057297 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/42671 | |
| dc.description.abstract | Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15057297&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.subject | Dengue | |
| dc.subject | Dengue Virus | |
| dc.subject | Humans | |
| dc.subject | Immune System | |
| dc.subject | Vaccines | |
| dc.subject | Clinical Epidemiology | |
| dc.subject | Immunology and Infectious Disease | |
| dc.subject | Pharmacy and Pharmaceutical Sciences | |
| dc.title | Dengue: defining protective versus pathologic immunity | |
| dc.type | Journal Article | |
| dc.source.journaltitle | The Journal of clinical investigation | |
| dc.source.volume | 113 | |
| dc.source.issue | 7 | |
| dc.identifier.legacyfulltext | https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1997&context=oapubs&unstamped=1 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/998 | |
| dc.identifier.contextkey | 659181 | |
| refterms.dateFOA | 2022-08-23T16:55:14Z | |
| html.description.abstract | <p>Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.</p> | |
| dc.identifier.submissionpath | oapubs/998 | |
| dc.contributor.department | Center for Infectious Disease and Vaccine Research | |
| dc.source.pages | 946-51 |
