UMass Chan Affiliations
Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2003-10-17Keywords
AnimalsMembrane Glycoproteins
Mice
NADPH Oxidase
Neutrophils
Receptors, Cell Surface
Toll-Like Receptor 2
Toll-Like Receptors
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study (see the related article beginning on page 1234) reports how TLR2 expression by endothelia is locally upregulated by the action of activated polymorphonuclear neutrophils via an unprecedented mechanism involving cell-cell interaction and NAD(P)H oxidase. The report reveals yet another way in which the primordial innate immune system is remarkably complex.Source
J Clin Invest. 2003 Oct;112(8):1136-7. Link to article on publisher's siteDOI
10.1172/JCI20040Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42672PubMed ID
14561697Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1172/JCI20040
