Receptor "cross talk" in innate immunity
| dc.contributor.author | Latz, Eicke | |
| dc.contributor.author | Golenbock, Douglas T. | |
| dc.date | 2022-08-11T08:10:05.000 | |
| dc.date.accessioned | 2022-08-23T16:55:14Z | |
| dc.date.available | 2022-08-23T16:55:14Z | |
| dc.date.issued | 2003-10-17 | |
| dc.date.submitted | 2008-10-31 | |
| dc.identifier.citation | J Clin Invest. 2003 Oct;112(8):1136-7. <a href="http://dx.doi.org/10.1172/JCI20040">Link to article on publisher's site</a> | |
| dc.identifier.issn | 0021-9738 (Print) | |
| dc.identifier.doi | 10.1172/JCI20040 | |
| dc.identifier.pmid | 14561697 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/42672 | |
| dc.description.abstract | Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study (see the related article beginning on page 1234) reports how TLR2 expression by endothelia is locally upregulated by the action of activated polymorphonuclear neutrophils via an unprecedented mechanism involving cell-cell interaction and NAD(P)H oxidase. The report reveals yet another way in which the primordial innate immune system is remarkably complex. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=14561697&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.subject | Animals | |
| dc.subject | Membrane Glycoproteins | |
| dc.subject | Mice | |
| dc.subject | NADPH Oxidase | |
| dc.subject | Neutrophils | |
| dc.subject | Receptors, Cell Surface | |
| dc.subject | Toll-Like Receptor 2 | |
| dc.subject | Toll-Like Receptors | |
| dc.subject | Immunology and Infectious Disease | |
| dc.title | Receptor "cross talk" in innate immunity | |
| dc.type | Journal Article | |
| dc.source.journaltitle | The Journal of clinical investigation | |
| dc.source.volume | 112 | |
| dc.source.issue | 8 | |
| dc.identifier.legacyfulltext | https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1998&context=oapubs&unstamped=1 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/oapubs/999 | |
| dc.identifier.contextkey | 659182 | |
| refterms.dateFOA | 2022-08-23T16:55:14Z | |
| html.description.abstract | <p>Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study (see the related article beginning on page 1234) reports how TLR2 expression by endothelia is locally upregulated by the action of activated polymorphonuclear neutrophils via an unprecedented mechanism involving cell-cell interaction and NAD(P)H oxidase. The report reveals yet another way in which the primordial innate immune system is remarkably complex.</p> | |
| dc.identifier.submissionpath | oapubs/999 | |
| dc.contributor.department | Division of Infectious Diseases and Immunology | |
| dc.source.pages | 1136-7 |
