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dc.contributor.authorProtasova, Maria Sergeevna
dc.contributor.authorAndreeva, Tatiana Vladimirovna
dc.contributor.authorRogaev, Evgeny I.
dc.date2022-08-11T08:10:06.000
dc.date.accessioned2022-08-23T16:55:22Z
dc.date.available2022-08-23T16:55:22Z
dc.date.issued2021-09-30
dc.date.submitted2022-05-18
dc.identifier.citation<p>Protasova MS, Andreeva TV, Rogaev EI. Factors Regulating the Activity of LINE1 Retrotransposons. Genes (Basel). 2021 Sep 30;12(10):1562. doi: 10.3390/genes12101562. PMID: 34680956; PMCID: PMC8535693. <a href="https://doi.org/10.3390/genes12101562">Link to article on publisher's site</a></p>
dc.identifier.issn2073-4425 (Linking)
dc.identifier.doi10.3390/genes12101562
dc.identifier.pmid34680956
dc.identifier.urihttp://hdl.handle.net/20.500.14038/42700
dc.description.abstractLINE-1 (L1) is a class of autonomous mobile genetic elements that form somatic mosaicisms in various tissues of the organism. The activity of L1 retrotransposons is strictly controlled by many factors in somatic and germ cells at all stages of ontogenesis. Alteration of L1 activity was noted in a number of diseases: in neuropsychiatric and autoimmune diseases, as well as in various forms of cancer. Altered activity of L1 retrotransposons for some pathologies is associated with epigenetic changes and defects in the genes involved in their repression. This review discusses the molecular genetic mechanisms of the retrotransposition and regulation of the activity of L1 elements. The contribution of various factors controlling the expression and distribution of L1 elements in the genome occurs at all stages of the retrotransposition. The regulation of L1 elements at the transcriptional, post-transcriptional and integration into the genome stages is described in detail. Finally, this review also focuses on the evolutionary aspects of L1 accumulation and their interplay with the host regulation system.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34680956&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectL1 silencing
dc.subjectLINE-1 retrotransposons
dc.subjectregulation
dc.subjectrepetitive elements
dc.subjectGenetics and Genomics
dc.subjectMolecular Biology
dc.subjectNucleic Acids, Nucleotides, and Nucleosides
dc.titleFactors Regulating the Activity of LINE1 Retrotransposons
dc.typeArticle
dc.source.journaltitleGenes
dc.source.volume12
dc.source.issue10
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5979&amp;context=oapubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/oapubs/4944
dc.identifier.contextkey29245051
refterms.dateFOA2022-08-23T16:55:22Z
html.description.abstract<p>LINE-1 (L1) is a class of autonomous mobile genetic elements that form somatic mosaicisms in various tissues of the organism. The activity of L1 retrotransposons is strictly controlled by many factors in somatic and germ cells at all stages of ontogenesis. Alteration of L1 activity was noted in a number of diseases: in neuropsychiatric and autoimmune diseases, as well as in various forms of cancer. Altered activity of L1 retrotransposons for some pathologies is associated with epigenetic changes and defects in the genes involved in their repression. This review discusses the molecular genetic mechanisms of the retrotransposition and regulation of the activity of L1 elements. The contribution of various factors controlling the expression and distribution of L1 elements in the genome occurs at all stages of the retrotransposition. The regulation of L1 elements at the transcriptional, post-transcriptional and integration into the genome stages is described in detail. Finally, this review also focuses on the evolutionary aspects of L1 accumulation and their interplay with the host regulation system.</p>
dc.identifier.submissionpathoapubs/4944
dc.contributor.departmentDepartment of Psychiatry
dc.source.pages1562


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Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).