TBK1 has a new Akt

Shaw, Leslie M.

dc.contributor.author	Shaw, Leslie M.
dc.date	2022-08-11T08:10:06.000
dc.date.accessioned	2022-08-23T16:55:26Z
dc.date.available	2022-08-23T16:55:26Z
dc.date.issued	2021-09-24
dc.date.submitted	2022-06-02
dc.identifier.citation	<p>Shaw LM. TBK1 has a new Akt. J Biol Chem. 2021 Oct;297(4):101244. doi: 10.1016/j.jbc.2021.101244. Epub 2021 Sep 24. PMID: 34563542; PMCID: PMC8498460. <a href="https://doi.org/10.1016/j.jbc.2021.101244">Link to article on publisher's site</a></p>
dc.identifier.issn	0021-9258 (Linking)
dc.identifier.doi	10.1016/j.jbc.2021.101244
dc.identifier.pmid	34563542
dc.identifier.uri	http://hdl.handle.net/20.500.14038/42712
dc.description.abstract	TANK-binding kinase 1 (TBK1) is a noncanonical IkappaB kinase that plays an essential role in the innate immune response to foreign pathogens. Recent studies have highlighted additional roles for TBK1 in the regulation of metabolism, although the mechanisms of this regulation have not been well characterized. In a recent issue, Tooley et al. demonstrated that TBK1-dependent activation of downstream kinase Akt is mediated via mechanistic target of rapamycin complex 2. This novel action of TBK1 reveals a key role for this kinase in the regulation of cellular metabolism and growth by diverse environmental inputs.
dc.language.iso	en_US
dc.relation	<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34563542&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights	Copyright © 2021 The Author. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	Biochemistry, Biophysics, and Structural Biology
dc.title	TBK1 has a new Akt
dc.type	Response or Comment
dc.source.journaltitle	The Journal of biological chemistry
dc.source.volume	297
dc.source.issue	4
dc.identifier.legacyfulltext	https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5991&context=oapubs&unstamped=1
dc.identifier.legacycoverpage	https://escholarship.umassmed.edu/oapubs/4956
dc.identifier.contextkey	29511289
refterms.dateFOA	2022-08-23T16:55:26Z
html.description.abstract	<p>TANK-binding kinase 1 (TBK1) is a noncanonical IkappaB kinase that plays an essential role in the innate immune response to foreign pathogens. Recent studies have highlighted additional roles for TBK1 in the regulation of metabolism, although the mechanisms of this regulation have not been well characterized. In a recent issue, Tooley et al. demonstrated that TBK1-dependent activation of downstream kinase Akt is mediated via mechanistic target of rapamycin complex 2. This novel action of TBK1 reveals a key role for this kinase in the regulation of cellular metabolism and growth by diverse environmental inputs.</p>
dc.identifier.submissionpath	oapubs/4956
dc.contributor.department	Department of Molecular, Cell and Cancer Biology
dc.source.pages	101244