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UMass Chan Affiliations
Department of Obstetrics and GynecologyDocument Type
Journal ArticlePublication Date
2014-10-01Keywords
FemaleHumans
Papillomaviridae
Papillomavirus Infections
Risk Factors
Vulvar Neoplasms
HPV infection
chemoradiation
sentinel node
vulvar carcinoma
vulvar intraepithelial neoplasia
Female Urogenital Diseases and Pregnancy Complications
Neoplasms
Obstetrics and Gynecology
Oncology
Women's Health
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Show full item recordAbstract
Vulvar carcinoma is an uncommon tumor that is seen most often in older women. Subtle symptoms such as pruritus should prompt examination and targeted biopsy in all women as this disease can be successfully treated even in elderly, frail individuals. Vulvar cancer has a bimodal age distribution and is seen in both young and older women with risk factors including human papillomavirus (HPV) infection, smoking, and vulvar skin diseases (i.e., lichen sclerosus). This cancer is staged surgically, with an update in 2009 incorporating prognostic factors. The treatment of vulvar carcinoma has evolved to include more conservative surgical techniques that provide improved cure rates with emphasis on minimizing morbidity. Advanced and metastatic lesions are now treated with chemoradiation which produces substantial cure rates with decreased morbidity. Promising areas of research in vulvar cancer include refinement of sentinel lymph node biopsy, prevention of lymphedema, and preservation of sexual function following treatment.Source
Best Pract Res Clin Obstet Gynaecol. 2014 Oct;28(7):959-66. doi: 10.1016/j.bpobgyn.2014.07.001. Epub 2014 Jul 17. Link to article on publisher's siteDOI
10.1016/j.bpobgyn.2014.07.001Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42760PubMed ID
25151473Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.bpobgyn.2014.07.001