Soluble endoglin for the prediction of preeclampsia in a high risk cohort
Authors
Maynard, Sharon E.Moore Simas, Tiffany A.
Bur, Lana
Crawford, Sybil L.
Solitro, Matthew J.
Meyer, Bruce A.
UMass Chan Affiliations
Department of Obstetrics and GynecologyDepartment of Medicine, Division of Preventive and Behavioral Medicine
Document Type
Journal ArticlePublication Date
2010-07-31Keywords
AdultAntigens, CD
Biological Markers
Enzyme-Linked Immunosorbent Assay
Female
Humans
Pre-Eclampsia
Pregnancy
Pregnancy Proteins
Pregnancy, High-Risk
Pregnancy, Multiple
Receptors, Cell Surface
Risk Factors
Vascular Endothelial Growth Factor Receptor-1
Obstetrics and Gynecology
Metadata
Show full item recordAbstract
OBJECTIVES: To evaluate soluble endoglin (sEng) and the soluble fms-like tyrosine kinase 1 (sFlt1) to placental growth factor (PlGF) ratio for the prediction of preeclampsia in high-risk women, and to evaluate differences in sEng between women with high-risk singleton and multiple gestation pregnancies. STUDY DESIGN: We collected serial serum specimens from 119 women at high preeclampsia risk. sEng, sFlt1 and PlGF were measured by ELISA. RESULTS: Among subjects who did not develop preeclampsia, mean serum sEng was significantly higher in those with multiple gestation pregnancies vs. high-risk singletons. Among women with singleton gestations, mean serum sEng was higher in subjects who developed early-onset (<34 >weeks) and late-onset (>or= 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks and 28 weeks gestation onward, respectively. The within-woman rate of change of sEng was also higher in women who later developed preeclampsia. CONCLUSIONS: sEng is higher in women with multiple gestations vs. high-risk singleton pregnancies. In high-risk women, serum sEng is increased prior to preeclampsia onset.Source
Hypertens Pregnancy. 2010;29(3):330-41. Link to article on publisher's siteDOI
10.3109/10641950902968684Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42850PubMed ID
20670156Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.3109/10641950902968684