• Login
    View Item 
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Radiology
    • Radiology Publications
    • View Item
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Radiology
    • Radiology Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywords

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Gartland, Alison
    Mason-Savas, April
    Yang, Meilheng
    MacKay, Carole A.
    Birnbaum, Mark J.
    Odgren, Paul R.
    UMass Chan Affiliations
    Department of Orthopedics and Physical Rehabilitation
    Department of Cell Biology
    Document Type
    Journal Article
    Publication Date
    2009-11-07
    Keywords
    Animals
    Bone Development
    Bone Diseases, Developmental
    Cartilage
    Chondrocytes
    Growth Plate
    Immunohistochemistry
    Macrophage Colony-Stimulating Factor
    Neovascularization, Physiologic
    Osteopetrosis
    Rats
    Rats, Mutant Strains
    Cell Biology
    Show allShow less
    
    Metadata
    Show full item record
    Link to Full Text
    http://dx.doi.org/10.2353/ajpath.2009.090185
    Abstract
    The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on the metaphyseal side of the growth plate during endochondral bone growth. The putative role of septoclasts is to break down the terminal transverse septum of growth plate cartilage and permit capillaries to bud into the lower hypertrophic zone. This process fails in osteoclast-deficient, osteopetrotic animal models, resulting in a progressive growth plate dysplasia. The toothless rat is severely osteopetrotic because of a frameshift mutation in the colony-stimulating factor-1 (CSF-1) gene (Csf1(tl)). Whereas CSF-1 injections quickly restore endosteal osteoclast populations, they do not improve the chondrodysplasia. We therefore investigated septoclast populations in Csf1(tl)/Csf1(tl) rats and wild-type littermates, with and without CSF-1 treatment, at 2 weeks, before the dysplasia is pronounced, and at 4 weeks, by which time it is severe. Tibial sections were immunolabeled for cathepsin B and septoclasts were counted. Csf1(tl)/Csf1(tl) mutants had significant reductions in septoclasts at both times, although they were more pronounced at 4 weeks. CSF-1 injections increased counts in wild-type and mutant animals at both times, restoring mutants to normal levels at 2 weeks. In all of the mutants, septoclasts seemed misoriented and had abnormal ultrastructure. We conclude that CSF-1 promotes angiogenesis at the chondroosseous junction, but that, in Csf1(tl)/Csf1(tl) rats, septoclasts are unable to direct their degradative activity appropriately, implying a capillary guidance role for locally supplied CSF-1.
    Source
    Am J Pathol. 2009 Dec;175(6):2668-75. Epub 2009 Nov 5. Link to article on publisher's site
    DOI
    10.2353/ajpath.2009.090185
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/42874
    PubMed ID
    19893052
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.2353/ajpath.2009.090185
    Scopus Count
    Collections
    Radiology Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.