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dc.contributor.authorFilion, Tera M.
dc.contributor.authorXu, Jianwen
dc.contributor.authorPrasad, Manju L.
dc.contributor.authorSong, Jie
dc.date2022-08-11T08:10:07.000
dc.date.accessioned2022-08-23T16:56:24Z
dc.date.available2022-08-23T16:56:24Z
dc.date.issued2011-02-03
dc.date.submitted2011-05-26
dc.identifier.citationBiomaterials. 2011 Feb;32(4):985-91. Epub 2010 Oct 30. <a href="http://dx.doi.org/10.1016/j.biomaterials.2010.10.012">Link to article on publisher's site</a>
dc.identifier.issn0142-9612 (Linking)
dc.identifier.doi10.1016/j.biomaterials.2010.10.012
dc.identifier.pmid21040968
dc.identifier.urihttp://hdl.handle.net/20.500.14038/42920
dc.description.abstractTo explore the safe use of thermal-responsive shape memory polymers (SMPs) as minimally invasive tissue scaffolds, we recently developed a class of biodegradable POSS-SMP nanocomposites exhibiting stable temporary shape fixing and facile shape recovery within a narrow window of physiological temperatures. The materials were covalently crosslinked from star-branched building blocks consisting a bioinert polyhedral oligomeric silsesquioxane (POSS) core and 8 degradable poly(D,L-lactide) (PLA) arms. Here we examine the degradation profiles and immunogenicity of POSS-SMPs as a function of the PLA arm lengths using a rat subcutaneous implantation model. We show that POSS-SMPs elicited a mild foreign body type immune response upon implantation. The degradation rates of POSS-SMPs, both in vitro and in vivo, inversely correlated with the length of the PLA chains within the crosslinked amorphous network. Upon in vivo degradation of POSS-SMPs, a second acute inflammatory response was elicited locally, and the inflammation was able to resolve over time without medical interventions. One year after the implantation of POSS-SMPs, no pathologic abnormalities were detected from the vital/scavenger organs examined. These minimally immunogenic and biodegradable SMPs are promising candidates for scaffold-assisted tissue repair where both facile surgical delivery and controlled degradation of the scaffold are desired for achieving optimal short-term and long-term clinical outcomes.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21040968&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.biomaterials.2010.10.012
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectForeign-Body Reaction
dc.subjectImplants, Experimental
dc.subjectMale
dc.subjectMaterials Testing
dc.subjectMolecular Structure
dc.subjectNanocomposites
dc.subjectPolymers
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subject*Temperature
dc.subjectTissue Engineering
dc.subjectTissue Scaffolds
dc.subjectOrthopedics
dc.subjectRehabilitation and Therapy
dc.titleIn vivo tissue responses to thermal-responsive shape memory polymer nanocomposites
dc.typeJournal Article
dc.source.journaltitleBiomaterials
dc.source.volume32
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/ortho_pp/12
dc.identifier.contextkey2032250
html.description.abstract<p>To explore the safe use of thermal-responsive shape memory polymers (SMPs) as minimally invasive tissue scaffolds, we recently developed a class of biodegradable POSS-SMP nanocomposites exhibiting stable temporary shape fixing and facile shape recovery within a narrow window of physiological temperatures. The materials were covalently crosslinked from star-branched building blocks consisting a bioinert polyhedral oligomeric silsesquioxane (POSS) core and 8 degradable poly(D,L-lactide) (PLA) arms. Here we examine the degradation profiles and immunogenicity of POSS-SMPs as a function of the PLA arm lengths using a rat subcutaneous implantation model. We show that POSS-SMPs elicited a mild foreign body type immune response upon implantation. The degradation rates of POSS-SMPs, both in vitro and in vivo, inversely correlated with the length of the PLA chains within the crosslinked amorphous network. Upon in vivo degradation of POSS-SMPs, a second acute inflammatory response was elicited locally, and the inflammation was able to resolve over time without medical interventions. One year after the implantation of POSS-SMPs, no pathologic abnormalities were detected from the vital/scavenger organs examined. These minimally immunogenic and biodegradable SMPs are promising candidates for scaffold-assisted tissue repair where both facile surgical delivery and controlled degradation of the scaffold are desired for achieving optimal short-term and long-term clinical outcomes.</p>
dc.identifier.submissionpathortho_pp/12
dc.contributor.departmentDepartment of Orthopedics and Physical Rehabilitation
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages985-91


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