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    (alpha-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging

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    Authors
    Chen, Guanying
    Shen, Jie
    Ohulchansky, Tymish Y.
    Patel, Nayan J.
    Kutikov, Artem
    Li, Zhipeng
    Song, Jie
    Pandey, Ravindra K.
    Agren, Hans
    Prasad, Paras N.
    Han, Gang
    Show allShow less
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Department of Cell and Developmental Biology
    Department of Orthopedics and Physical Rehabilitation
    Document Type
    Journal Article
    Publication Date
    2012-09-25
    Keywords
    Animals
    Calcium Fluoride
    Contrast Media
    Femur
    Fluorides
    Infrared Rays
    Materials Testing
    Mice
    Microscopy, Fluorescence
    Molecular Conformation
    Muscle, Skeletal
    Nanoparticles
    Particle Size
    Porosity
    Rats
    Swine
    Yttrium
    Bioimaging and Biomedical Optics
    Cell Biology
    Nanoscience and Nanotechnology
    Orthopedics
    Show allShow less
    
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    Link to Full Text
    http://dx.doi.org/10.1021/nn302972r
    Abstract
    We describe the development of novel and biocompatible core/shell (alpha-NaYbF(4):Tm(3+))/CaF(2) nanoparticles that exhibit highly efficient NIR(in)-NIR(out) upconversion (UC) for high contrast and deep bioimaging. When excited at ~980 nm, these nanoparticles emit photoluminescence (PL) peaked at ~800 nm. The quantum yield of this UC PL under low power density excitation (~0.3 W/cm(2)) is 0.6 +/- 0.1%. This high UC PL efficiency is realized by suppressing surface quenching effects via heteroepitaxial growth of a biocompatible CaF(2) shell, which results in a 35-fold increase in the intensity of UC PL from the core. Small-animal whole-body UC PL imaging with exceptional contrast (signal-to-background ratio of 310) is shown using BALB/c mice intravenously injected with aqueously dispersed nanoparticles (700 pmol/kg). High-contrast UC PL imaging of deep tissues is also demonstrated, using a nanoparticle-loaded synthetic fibrous mesh wrapped around rat femoral bone and a cuvette with nanoparticle aqueous dispersion covered with a 3.2 cm thick animal tissue (pork).
    Source
    ACS Nano. 2012 Sep 25;6(9):8280-7. Epub 2012 Sep 4. Link to article on publisher's site
    DOI
    10.1021/nn302972r
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/42945
    PubMed ID
    22928629
    Notes

    Co-author Artem B. Kutikov is a doctoral student in the Cell Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1021/nn302972r
    Scopus Count
    Collections
    UMass Chan Faculty and Researcher Publications
    Orthopedics and Physical Rehabilitation Publications

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