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    Racial and ethnic disparities in disease activity in patients with rheumatoid arthritis

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    Authors
    Greenberg, Jeffrey D.
    Spruill, Tanya M.
    Shan, Ying
    Reed, George W.
    Kremer, Joel M.
    Potter, Jeffrey
    Yazici, Yusuf
    Ogedegbe, Gbenga
    Harrold, Leslie R.
    UMass Chan Affiliations
    Department of Medicine, Division of Preventive and Behavioral Medicine
    Department of Orthopedics and Physical Rehabilitation
    Document Type
    Journal Article
    Publication Date
    2013-12-01
    Keywords
    Arthritis, Rheumatoid
    Cohort Studies
    *Continental Population Groups
    *Ethnic Groups
    Health Status Disparities
    Humans
    Odds Ratio
    Risk Factors
    United States
    Disease activity
    Disparities
    Rheumatoid arthritis
    Clinical Epidemiology
    Epidemiology
    Musculoskeletal Diseases
    Rheumatology
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    Link to Full Text
    http://dx.doi.org/10.1016/j.amjmed.2013.09.002
    Abstract
    BACKGROUND: Observational studies of patients with rheumatoid arthritis have suggested that racial and ethnic disparities exist for minority populations. We compared disease activity and clinical outcomes across racial and ethnic groups using data from a large, contemporary US registry. METHODS: We analyzed data from 2 time periods (2005-2007 and 2010-2012). The Clinical Disease Activity Index was examined as both a continuous measure and a dichotomous measure of disease activity states. Outcomes were compared in a series of cross-sectional and longitudinal multivariable regression models. RESULTS: For 2005-2007, significant differences of mean disease activity level (P < .001) were observed across racial and ethnic groups. Over the 5-year period, modest improvements in disease activity were observed across all groups, including whites (3.7; 95% confidence interval [CI], 3.2-4.1) compared with African Americans (4.3; 95% CI, 2.7-5.8) and Hispanics (2.7; 95% CI, 1.2-4.3). For 2010-2012, significant differences of mean disease activity level persisted (P < .046) across racial and ethnic groups, ranging from 11.6 (95% CI, 10.4-12.8) in Hispanics to 10.7 (95% CI, 9.6-11.7) in whites. Remission rates remained significantly different across racial/ethnic groups across all models for 2010-2012, ranging from 22.7 (95% CI, 19.5-25.8) in African Americans to 27.4 (95% CI, 24.9-29.8) in whites. CONCLUSIONS: Despite improvements in disease activity across racial and ethnic groups over a 5-year period, disparities persist in disease activity and clinical outcomes for minority groups versus white patients.
    Source

    Greenberg JD, Spruill TM, Shan Y, Reed G, Kremer JM, Potter J, Yazici Y, Ogedegbe G, Harrold LR. Racial and ethnic disparities in disease activity in patients with rheumatoid arthritis. Am J Med. 2013 Dec;126(12):1089-98. doi:10.1016/j.amjmed.2013.09.002. Link to article on publisher's site

    DOI
    10.1016/j.amjmed.2013.09.002
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/42960
    PubMed ID
    24262723
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.amjmed.2013.09.002
    Scopus Count
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    UMass Chan Faculty and Researcher Publications
    Orthopedics and Physical Rehabilitation Publications

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