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    Arachidonic acid, eicosanoids, and fracture repair

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    Authors
    Wixted, John J.
    Fanning, Paul J.
    Rothkopf, Ian
    Stein, Gary S.
    Lian, Jane B.
    UMass Chan Affiliations
    Department of Cell Biology
    Department of Orthopedics and Physical Rehabilitation
    Document Type
    Journal Article
    Publication Date
    2010-08-26
    Keywords
    Animals
    Arachidonic Acid
    Cartilage, Articular
    Chondrogenesis
    Eicosanoids
    Fracture Healing
    Fractures, Bone
    Humans
    Inflammation
    Inflammation Mediators
    Leukotriene Antagonists
    Leukotrienes
    Orthopedics
    Rehabilitation and Therapy
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    Link to Full Text
    http://dx.doi.org/10.1097/BOT.0b013e3181f17b33
    Abstract
    Not all fractures heal well or rapidly in the adult skeleton, and basic scientists and clinicians continue to search for ways to make fractures heal more predictably. It is a fundamental tenet of orthopaedics that skeletal injury is followed by inflammation and that this inflammatory response is the first stage in a sequence of events that culminate in skeletal repair. Modulating this response can affect the inflammatory stage and in turn subsequent stages that are required for healing. Literally dozens of studies in animals dating back to the 1970s have investigated the effects of commonly used anti-inflammatory medications on prostaglandin synthesis and fracture repair with strikingly uniform results. More recently, investigators have begun examining other means of modulating the early inflammatory stages after fracture in an effort to enhance fracture healing. This article reviews recent investigations into the potential role of leukotrienes as negative regulators of fracture healing and potential pharmacologic use of medications that block this effect.
    Source
    J Orthop Trauma. 2010 Sep;24(9):539-42. Link to article on publisher's site
    DOI
    10.1097/BOT.0b013e3181f17b33
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/42976
    PubMed ID
    20736790
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1097/BOT.0b013e3181f17b33
    Scopus Count
    Collections
    UMass Chan Faculty and Researcher Publications
    Orthopedics and Physical Rehabilitation Publications

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